{
    "schema": 1,
    "fid": "ace-031",
    "type": "article",
    "object_id": 338,
    "title": "ACE-031: Reference Overview and Reconstitution Notes",
    "entity": "ACE-031: Reference Overview and Reconstitution Notes",
    "url": "https://www.preppinpeppers.com/blogs/the-lab/ace-031",
    "facts_url": "https://www.preppinpeppers.com/facts/ace-031",
    "currency": null,
    "tldr": "ACE-031 (ramatercept) is an experimental protein being studied for its effects on muscle mass. It is for research only and has not been approved by the FDA.",
    "facts": [
        {
            "id": "ace-031:title",
            "category": "identity",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "title",
            "value": "ACE-031: Reference Overview and Reconstitution Notes",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/ace-031"
        },
        {
            "id": "ace-031:published",
            "category": "identity",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "published",
            "value": "2026-08-15",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/ace-031"
        },
        {
            "id": "ace-031:author",
            "category": "identity",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "author",
            "value": "Preppin' Peppers Editorial Team",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/ace-031"
        },
        {
            "id": "ace-031:topics",
            "category": "identity",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "topics",
            "value": "Investigational, research",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/ace-031"
        },
        {
            "id": "ace-031:summary",
            "category": "content",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "summary",
            "value": "ACE-031 (ramatercept) is an experimental protein being studied for its effects on muscle mass. It is for research only and has not been approved by the FDA.",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/ace-031"
        },
        {
            "id": "ace-031:section-1",
            "category": "content",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "What it is",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/ace-031"
        },
        {
            "id": "ace-031:section-2",
            "category": "content",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "ACE-031",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/ace-031"
        },
        {
            "id": "ace-031:section-3",
            "category": "content",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "What it is",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/ace-031"
        },
        {
            "id": "ace-031:section-4",
            "category": "content",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Research context and categorization",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/ace-031"
        },
        {
            "id": "ace-031:section-5",
            "category": "content",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Status",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/ace-031"
        },
        {
            "id": "ace-031:section-6",
            "category": "content",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Reconstitution notes (general)",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/ace-031"
        },
        {
            "id": "ace-031:section-7",
            "category": "content",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Dilution and handling notes (compound-specific)",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/ace-031"
        },
        {
            "id": "ace-031:section-8",
            "category": "content",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Handling and storage",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/ace-031"
        },
        {
            "id": "ace-031:section-9",
            "category": "content",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Related reading",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/ace-031"
        },
        {
            "id": "ace-031:section-10",
            "category": "content",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Tools and supplies",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/ace-031"
        },
        {
            "id": "ace-031:section-12",
            "category": "content",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "What the research community gets wrong about ACE-031 (ramatercept)",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/ace-031"
        },
        {
            "id": "ace-031:product-gansulin-metal-peptide-pen",
            "category": "products",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "references product",
            "value": "Gansulin Pen · Reusable Click-Dial, 3 ml (1-60 Units)",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/products/gansulin-metal-peptide-pen"
        },
        {
            "id": "ace-031:product-gansulin-3ml-cartridge",
            "category": "products",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "references product",
            "value": "Gansulin-Compatible 3 ml Glass Cartridge for Pens (10-Pack)",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.preppinpeppers.com/products/gansulin-3ml-cartridge"
        },
        {
            "id": "ace-031:source-pubmed-ncbi-nlm-nih-gov",
            "category": "source",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "Campbell et al., Muscle Nerve 2017: Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial - pubmed.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://pubmed.ncbi.nlm.nih.gov/27462804/"
        },
        {
            "id": "ace-031:source-pubmed-ncbi-nlm-nih-gov-2",
            "category": "source",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "Attie et al., Muscle Nerve 2013: A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers - pubmed.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://pubmed.ncbi.nlm.nih.gov/23169607/"
        },
        {
            "id": "ace-031:source-pmc-ncbi-nlm-nih-gov",
            "category": "source",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "Cadena et al., PLoS One 2026: ACE-031, a soluble activin type IIB receptor, increases muscle mass and strength in the common marmoset (Callithrix jacchus) - pmc.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12904423/"
        },
        {
            "id": "ace-031:source-pmc-ncbi-nlm-nih-gov-2",
            "category": "source",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "Reichel et al., Drug Test Anal 2025: Gel Electrophoretic Detection of Black Market ACE-031 - pmc.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12489275/"
        },
        {
            "id": "ace-031:source-www-uniprot-org",
            "category": "source",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "UniProtKB/Swiss-Prot Q13705: Activin receptor type-2B (ACVR2B, Homo sapiens), UniProt release 2026-03 - www.uniprot.org",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://www.uniprot.org/uniprotkb/Q13705/entry"
        },
        {
            "id": "ace-031:source-clinicaltrials-gov",
            "category": "source",
            "entity": "ACE-031: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "ClinicalTrials.gov NCT00952887 (Phase 1, completed, first posted 2009-08-06): A Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of ACE-031 in Healthy Postmenopausal Women - clinicaltrials.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/ace-031)",
            "evidence": "https://clinicaltrials.gov/study/NCT00952887"
        }
    ],
    "buy": [],
    "faq": [
        {
            "q": "What is ACE-031 (ramatercept) and how does it work mechanistically?",
            "a": "ACE-031 is a soluble ActRIIB-IgG1 fusion protein that acts as a ligand trap, sequestering myostatin and other TGF-beta superfamily ligands before they bind cell-surface receptors, thereby modulating muscle-growth signaling pathways."
        },
        {
            "q": "Why was ACE-031 clinical development discontinued?",
            "a": "Trials were halted after participants experienced vascular side effects—nosebleeds, telangiectasias, and gum bleeding—attributed to off-target inhibition of BMP9, a protein required for blood vessel homeostasis."
        },
        {
            "q": "What is ACE-031's regulatory and WADA doping status?",
            "a": "ACE-031 has no FDA approval or marketing authorization. It is prohibited at all times under WADA Prohibited List section S4.3, which covers myostatin inhibitors and activin receptor type II inhibitors."
        }
    ],
    "jsonld": [
        {
            "@context": "https://schema.org",
            "@type": "Article",
            "headline": "ACE-031: Reference Overview and Reconstitution Notes",
            "url": "https://www.preppinpeppers.com/blogs/the-lab/ace-031",
            "mainEntityOfPage": "https://www.preppinpeppers.com/blogs/the-lab/ace-031",
            "datePublished": "2026-08-15",
            "dateModified": "2026-10-16",
            "author": {
                "@type": "Person",
                "name": "Preppin' Peppers Editorial Team"
            },
            "publisher": {
                "@type": "Organization",
                "name": "PreppinPeppers"
            },
            "description": "ACE-031 (ramatercept) is an experimental protein being studied for its effects on muscle mass. It is for research only and has not been approved by the FDA."
        },
        {
            "@context": "https://schema.org",
            "@type": "FAQPage",
            "url": "https://www.preppinpeppers.com/facts/ace-031",
            "mainEntity": [
                {
                    "@type": "Question",
                    "name": "What is ACE-031 (ramatercept) and how does it work mechanistically?",
                    "acceptedAnswer": {
                        "@type": "Answer",
                        "text": "ACE-031 is a soluble ActRIIB-IgG1 fusion protein that acts as a ligand trap, sequestering myostatin and other TGF-beta superfamily ligands before they bind cell-surface receptors, thereby modulating muscle-growth signaling pathways."
                    }
                },
                {
                    "@type": "Question",
                    "name": "Why was ACE-031 clinical development discontinued?",
                    "acceptedAnswer": {
                        "@type": "Answer",
                        "text": "Trials were halted after participants experienced vascular side effects—nosebleeds, telangiectasias, and gum bleeding—attributed to off-target inhibition of BMP9, a protein required for blood vessel homeostasis."
                    }
                },
                {
                    "@type": "Question",
                    "name": "What is ACE-031's regulatory and WADA doping status?",
                    "acceptedAnswer": {
                        "@type": "Answer",
                        "text": "ACE-031 has no FDA approval or marketing authorization. It is prohibited at all times under WADA Prohibited List section S4.3, which covers myostatin inhibitors and activin receptor type II inhibitors."
                    }
                }
            ]
        }
    ],
    "dates": {
        "published": "2026-08-15",
        "modified": "2026-10-16"
    }
}