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    "title": "Dead volume is stealing doses from your peptide pen",
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    "url": "https://www.preppinpeppers.com/blogs/the-lab/dead-volume-is-stealing-doses-from-your-peptide-pen",
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    "tldr": "Dead volume is the fixed hollow channel in a pen needle and cartridge connector that must fill with liquid before any measured volume can leave the pen.",
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            "value": "Dead volume is the fixed hollow channel in a pen needle and cartridge connector that must fill with liquid before any measured volume can leave the pen.",
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            "value": "What it is",
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            "value": "What dead volume actually is",
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            "value": "How to prime before the first draw",
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            "value": "Air bubbles and dead volume are two separate problems",
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            "value": "What the research community gets wrong about pen dead volume",
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            "value": "Bohannon, Postgrad Med 1999: Insulin delivery using pen devices. Simple-to-use tools may help young and old alike - pubmed.ncbi.nlm.nih.gov",
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            "value": "Chaves et al., Rev Esc Enferm USP 2017: Residual volume in vials of antibiotics used in pediatrics - pubmed.ncbi.nlm.nih.gov",
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        {
            "q": "What is dead volume in a peptide pen?",
            "a": "Dead volume is the fixed hollow channel running through the needle and connector that must be filled with liquid before any compound can exit the tip. It is a structural feature of every precision click-dial pen, not a defect."
        },
        {
            "q": "Why do I lose liquid every time I change the needle on my pen?",
            "a": "Whatever liquid fills the needle channel exits with the used needle when removed. This loss is expected; factor it into your total cartridge yield calculations before you begin a draw series."
        },
        {
            "q": "What is the difference between dead volume and air bubbles in a peptide cartridge?",
            "a": "Dead volume is a fixed structural space in the needle; it always requires priming. Air bubbles form inside the cartridge liquid from agitation and can be reduced by gentle rolling during reconstitution and tapping needle-side up before priming."
        }
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            "headline": "Dead volume is stealing doses from your peptide pen",
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            "description": "Dead volume is the fixed hollow channel in a pen needle and cartridge connector that must fill with liquid before any measured volume can leave the pen."
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                        "text": "Dead volume is the fixed hollow channel running through the needle and connector that must be filled with liquid before any compound can exit the tip. It is a structural feature of every precision click-dial pen, not a defect."
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                {
                    "@type": "Question",
                    "name": "Why do I lose liquid every time I change the needle on my pen?",
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                        "text": "Whatever liquid fills the needle channel exits with the used needle when removed. This loss is expected; factor it into your total cartridge yield calculations before you begin a draw series."
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                        "text": "Dead volume is a fixed structural space in the needle; it always requires priming. Air bubbles form inside the cartridge liquid from agitation and can be reduced by gentle rolling during reconstitution and tapping needle-side up before priming."
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        "published": "2026-08-15",
        "modified": "2026-10-16"
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