# Dermorphin: Reference Overview and Reconstitution Notes - facts

Canonical page: https://www.preppinpeppers.com/blogs/the-lab/dermorphin
Type: Lab article

## TL;DR

Dermorphin is a natural seven-amino-acid opioid peptide first found in Phyllomedusa frog skin, studied at the mu-opioid receptor. Research reference notes.

## Facts Index

| Fact ID | Category | Entity | Attribute | Value | Source | Evidence |
|---|---|---|---|---|---|---|
| dermorphin:title | identity | Dermorphin: Reference Overview and Reconstitution Notes | title | Dermorphin: Reference Overview and Reconstitution Notes | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/blogs/the-lab/dermorphin |
| dermorphin:published | identity | Dermorphin: Reference Overview and Reconstitution Notes | published | 2026-08-15 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/blogs/the-lab/dermorphin |
| dermorphin:author | identity | Dermorphin: Reference Overview and Reconstitution Notes | author | Preppin' Peppers Editorial Team | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/blogs/the-lab/dermorphin |
| dermorphin:topics | identity | Dermorphin: Reference Overview and Reconstitution Notes | topics | research, Research-only | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/blogs/the-lab/dermorphin |
| dermorphin:summary | content | Dermorphin: Reference Overview and Reconstitution Notes | summary | Dermorphin is a natural seven-amino-acid opioid peptide first found in Phyllomedusa frog skin, studied at the mu-opioid receptor. Research reference notes. | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/blogs/the-lab/dermorphin |
| dermorphin:section-1 | content | Dermorphin: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/blogs/the-lab/dermorphin |
| dermorphin:section-2 | content | Dermorphin: Reference Overview and Reconstitution Notes | section | Dermorphin | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/blogs/the-lab/dermorphin |
| dermorphin:section-3 | content | Dermorphin: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/blogs/the-lab/dermorphin |
| dermorphin:section-4 | content | Dermorphin: Reference Overview and Reconstitution Notes | section | Research context and categorization | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/blogs/the-lab/dermorphin |
| dermorphin:section-5 | content | Dermorphin: Reference Overview and Reconstitution Notes | section | Status | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/blogs/the-lab/dermorphin |
| dermorphin:section-6 | content | Dermorphin: Reference Overview and Reconstitution Notes | section | Reconstitution notes (general) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/blogs/the-lab/dermorphin |
| dermorphin:section-7 | content | Dermorphin: Reference Overview and Reconstitution Notes | section | Dilution and handling notes (compound-specific) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/blogs/the-lab/dermorphin |
| dermorphin:section-8 | content | Dermorphin: Reference Overview and Reconstitution Notes | section | Handling and storage | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/blogs/the-lab/dermorphin |
| dermorphin:section-9 | content | Dermorphin: Reference Overview and Reconstitution Notes | section | Related reading | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/blogs/the-lab/dermorphin |
| dermorphin:section-10 | content | Dermorphin: Reference Overview and Reconstitution Notes | section | Tools and supplies | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/blogs/the-lab/dermorphin |
| dermorphin:section-12 | content | Dermorphin: Reference Overview and Reconstitution Notes | section | What the research community gets wrong about dermorphin | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/blogs/the-lab/dermorphin |
| dermorphin:source-pubmed-ncbi-nlm-nih-gov | source | Dermorphin: Reference Overview and Reconstitution Notes | cites | Jiang et al. 2013 - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://pubmed.ncbi.nlm.nih.gov/23872443/ |
| dermorphin:source-pmc-ncbi-nlm-nih-gov | source | Dermorphin: Reference Overview and Reconstitution Notes | cites | Goebel-Stengel et al. 2011 - pmc.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://pmc.ncbi.nlm.nih.gov/articles/PMC3290000/ |
| dermorphin:source-pubmed-ncbi-nlm-nih-gov-2 | source | Dermorphin: Reference Overview and Reconstitution Notes | cites | Grohganz et al. 2004 - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://pubmed.ncbi.nlm.nih.gov/14757490/ |
| dermorphin:product-gansulin-metal-peptide-pen | products | Dermorphin: Reference Overview and Reconstitution Notes | references product | Gansulin Pen · Reusable Click-Dial, 3 ml (1-60 Units) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/products/gansulin-metal-peptide-pen |
| dermorphin:product-gansulin-3ml-cartridge | products | Dermorphin: Reference Overview and Reconstitution Notes | references product | Gansulin-Compatible 3 ml Glass Cartridge for Pens (10-Pack) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://www.preppinpeppers.com/products/gansulin-3ml-cartridge |
| dermorphin:source-pubchem-ncbi-nlm-nih-gov | source | Dermorphin: Reference Overview and Reconstitution Notes | cites | NCBI PubChem CID 5485199: Dermorphin (C40H50N8O10) - pubchem.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://pubchem.ncbi.nlm.nih.gov/compound/5485199 |
| dermorphin:source-drugs-ncats-io | source | Dermorphin: Reference Overview and Reconstitution Notes | cites | NCATS Inxight Drugs , Dermorphin, selective mu-opioid receptor agonist (NIH/NCATS) - drugs.ncats.io | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://drugs.ncats.io/drug/2SEC01B703 |
| dermorphin:source-pmc-ncbi-nlm-nih-gov-2 | source | Dermorphin: Reference Overview and Reconstitution Notes | cites | Negri et al., Br J Pharmacol 1995: Production of antinociception by peripheral administration of [Lys7]dermorphin, a naturally occurring peptide with high affinity for mu-opioid receptors - pmc.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://pmc.ncbi.nlm.nih.gov/articles/PMC1510172/ |
| dermorphin:source-pubmed-ncbi-nlm-nih-gov-3 | source | Dermorphin: Reference Overview and Reconstitution Notes | cites | Mizoguchi et al., Peptides 2011: Dermorphin tetrapeptide analogs as potent and long-lasting analgesics with pharmacological profiles distinct from morphine - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://pubmed.ncbi.nlm.nih.gov/21126548/ |
| dermorphin:source-pubmed-ncbi-nlm-nih-gov-4 | source | Dermorphin: Reference Overview and Reconstitution Notes | cites | Yamashita et al., Chem Pharm Bull (Tokyo) 1996: Structure-activity relationships of dermorphin analogues containing chiral piperazin-2-one and piperazine derivatives - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://pubmed.ncbi.nlm.nih.gov/8681417/ |
| dermorphin:source-pubmed-ncbi-nlm-nih-gov-5 | source | Dermorphin: Reference Overview and Reconstitution Notes | cites | Melchiorri and Negri, Gen Pharmacol 1996: The dermorphin peptide family - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/dermorphin) | https://pubmed.ncbi.nlm.nih.gov/8981054/ |

## FAQ

### What is dermorphin and where does it come from?

Dermorphin is a naturally occurring heptapeptide first isolated from the skin of South American Phyllomedusa frogs. Its sequence is Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂, with a rare D-alanine at position 2 that resists enzymatic degradation.

### What receptor does dermorphin bind to in laboratory studies?

Scientific literature describes dermorphin as a highly potent, selective mu-opioid receptor agonist, reported to be many times more potent than morphine at that receptor in vitro. It is used as a research tool in antinociception and receptor-binding studies.

### How is dermorphin lyophilized powder reconstituted for lab use?

Calculate volume as mg ÷ target mg/mL (e.g., 5 mg ÷ 2 mg/mL = 2.5 mL bacteriostatic water). Inject solvent gently along the vial wall, swirl — do not shake — until dissolved, then label with concentration and date before storing per lab protocol.

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