# Epitalon: Reference Overview and Reconstitution Notes - facts

Canonical page: https://www.preppinpeppers.com/blogs/the-lab/epitalon
Type: Lab article

## TL;DR

Epitalon is a synthetic pineal-derived tetrapeptide of the Khavinson bioregulator family, studied in longevity research. Not FDA-approved; reconstitution notes.

## Facts Index

| Fact ID | Category | Entity | Attribute | Value | Source | Evidence |
|---|---|---|---|---|---|---|
| epitalon:title | identity | Epitalon: Reference Overview and Reconstitution Notes | title | Epitalon: Reference Overview and Reconstitution Notes | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/blogs/the-lab/epitalon |
| epitalon:published | identity | Epitalon: Reference Overview and Reconstitution Notes | published | 2026-08-15 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/blogs/the-lab/epitalon |
| epitalon:last-reviewed | identity | Epitalon: Reference Overview and Reconstitution Notes | last reviewed | 2026-10-03 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/blogs/the-lab/epitalon |
| epitalon:author | identity | Epitalon: Reference Overview and Reconstitution Notes | author | Preppin' Peppers Editorial Team | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/blogs/the-lab/epitalon |
| epitalon:topics | identity | Epitalon: Reference Overview and Reconstitution Notes | topics | research, Research-only | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/blogs/the-lab/epitalon |
| epitalon:summary | content | Epitalon: Reference Overview and Reconstitution Notes | summary | Epitalon is a synthetic pineal-derived tetrapeptide of the Khavinson bioregulator family, studied in longevity research. Not FDA-approved; reconstitution notes. | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/blogs/the-lab/epitalon |
| epitalon:section-1 | content | Epitalon: Reference Overview and Reconstitution Notes | section | Epitalon | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/blogs/the-lab/epitalon |
| epitalon:section-2 | content | Epitalon: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/blogs/the-lab/epitalon |
| epitalon:section-3 | content | Epitalon: Reference Overview and Reconstitution Notes | section | Research context and categorization | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/blogs/the-lab/epitalon |
| epitalon:section-4 | content | Epitalon: Reference Overview and Reconstitution Notes | section | Status | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/blogs/the-lab/epitalon |
| epitalon:section-5 | content | Epitalon: Reference Overview and Reconstitution Notes | section | Reconstitution notes (general) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/blogs/the-lab/epitalon |
| epitalon:section-6 | content | Epitalon: Reference Overview and Reconstitution Notes | section | Dilution and handling notes (compound-specific) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/blogs/the-lab/epitalon |
| epitalon:section-7 | content | Epitalon: Reference Overview and Reconstitution Notes | section | Handling and storage | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/blogs/the-lab/epitalon |
| epitalon:section-8 | content | Epitalon: Reference Overview and Reconstitution Notes | section | Related reading | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/blogs/the-lab/epitalon |
| epitalon:section-9 | content | Epitalon: Reference Overview and Reconstitution Notes | section | Tools and supplies | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/blogs/the-lab/epitalon |
| epitalon:section-11 | content | Epitalon: Reference Overview and Reconstitution Notes | section | What the research community gets wrong about Epitalon handling | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/blogs/the-lab/epitalon |
| epitalon:product-gansulin-metal-peptide-pen | products | Epitalon: Reference Overview and Reconstitution Notes | references product | Gansulin Pen · Reusable Click-Dial, 3 ml (1-60 Units) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/products/gansulin-metal-peptide-pen |
| epitalon:product-gansulin-3ml-cartridge | products | Epitalon: Reference Overview and Reconstitution Notes | references product | Gansulin-Compatible 3 ml Glass Cartridge for Pens (10-Pack) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://www.preppinpeppers.com/products/gansulin-3ml-cartridge |
| epitalon:source-pubchem-ncbi-nlm-nih-gov | source | Epitalon: Reference Overview and Reconstitution Notes | cites | NCBI PubChem CID 219042: Epitalon (C14H22N4O9) - pubchem.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://pubchem.ncbi.nlm.nih.gov/compound/219042 |
| epitalon:source-pubmed-ncbi-nlm-nih-gov | source | Epitalon: Reference Overview and Reconstitution Notes | cites | Araj et al., Int J Mol Sci 2025: Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://pubmed.ncbi.nlm.nih.gov/40141333/ |
| epitalon:source-pubmed-ncbi-nlm-nih-gov-2 | source | Epitalon: Reference Overview and Reconstitution Notes | cites | Sibarov et al., Neuro Endocrinol Lett 2002: Epitalon influences pineal secretion in stress-exposed rats in the daytime - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://pubmed.ncbi.nlm.nih.gov/12500171/ |
| epitalon:source-pubmed-ncbi-nlm-nih-gov-3 | source | Epitalon: Reference Overview and Reconstitution Notes | cites | Khavinson VKh, Neuro Endocrinol Lett 2002: Peptides and Ageing - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://pubmed.ncbi.nlm.nih.gov/12374906/ |
| epitalon:source-pmc-ncbi-nlm-nih-gov | source | Epitalon: Reference Overview and Reconstitution Notes | cites | Yue et al., Aging (Albany NY) 2022: Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro - pmc.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) | https://pmc.ncbi.nlm.nih.gov/articles/PMC9037278/ |

## FAQ

### What is Epitalon and what is its amino acid sequence?

Epitalon (also Epithalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG) and a molecular weight of ~390 g/mol, designed to mimic epithalamin, a longer protein derived from the pineal gland.

### Is Epitalon FDA-approved, and what is its regulatory status as of 2026?

No. Epitalon has no FDA-approved use, is classified as a research chemical not for human consumption, and as of 2026 was removed from the FDA 503A compounding category and placed under formal advisory review.

### What is Epitalon studied for in laboratory and animal research?

It is studied in cell and animal models for telomerase activation, telomere elongation, melatonin regulation, antioxidant activity, and lifespan endpoints. No controlled human clinical trial has confirmed these effects.

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