# Follistatin: Reference Overview and Reconstitution Notes - facts

Canonical page: https://www.preppinpeppers.com/blogs/the-lab/follistatin
Type: Lab article

## TL;DR

Follistatin is a naturally produced glycoprotein that binds and blocks myostatin and activin, studied in muscle and metabolic research. Not FDA-approved.

## Facts Index

| Fact ID | Category | Entity | Attribute | Value | Source | Evidence |
|---|---|---|---|---|---|---|
| follistatin:title | identity | Follistatin: Reference Overview and Reconstitution Notes | title | Follistatin: Reference Overview and Reconstitution Notes | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/blogs/the-lab/follistatin |
| follistatin:published | identity | Follistatin: Reference Overview and Reconstitution Notes | published | 2026-08-15 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/blogs/the-lab/follistatin |
| follistatin:author | identity | Follistatin: Reference Overview and Reconstitution Notes | author | Preppin' Peppers Editorial Team | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/blogs/the-lab/follistatin |
| follistatin:topics | identity | Follistatin: Reference Overview and Reconstitution Notes | topics | research, Research-only | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/blogs/the-lab/follistatin |
| follistatin:summary | content | Follistatin: Reference Overview and Reconstitution Notes | summary | Follistatin is a naturally produced glycoprotein that binds and blocks myostatin and activin, studied in muscle and metabolic research. Not FDA-approved. | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/blogs/the-lab/follistatin |
| follistatin:section-1 | content | Follistatin: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/blogs/the-lab/follistatin |
| follistatin:section-2 | content | Follistatin: Reference Overview and Reconstitution Notes | section | Follistatin | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/blogs/the-lab/follistatin |
| follistatin:section-3 | content | Follistatin: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/blogs/the-lab/follistatin |
| follistatin:section-4 | content | Follistatin: Reference Overview and Reconstitution Notes | section | Research context and categorization | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/blogs/the-lab/follistatin |
| follistatin:section-5 | content | Follistatin: Reference Overview and Reconstitution Notes | section | Status | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/blogs/the-lab/follistatin |
| follistatin:section-6 | content | Follistatin: Reference Overview and Reconstitution Notes | section | Reconstitution notes (general) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/blogs/the-lab/follistatin |
| follistatin:section-7 | content | Follistatin: Reference Overview and Reconstitution Notes | section | Dilution and handling notes (compound-specific) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/blogs/the-lab/follistatin |
| follistatin:section-8 | content | Follistatin: Reference Overview and Reconstitution Notes | section | Handling and storage | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/blogs/the-lab/follistatin |
| follistatin:section-9 | content | Follistatin: Reference Overview and Reconstitution Notes | section | Related reading | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/blogs/the-lab/follistatin |
| follistatin:section-10 | content | Follistatin: Reference Overview and Reconstitution Notes | section | Tools and supplies | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/blogs/the-lab/follistatin |
| follistatin:section-12 | content | Follistatin: Reference Overview and Reconstitution Notes | section | What the research community gets wrong about Follistatin | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/blogs/the-lab/follistatin |
| follistatin:product-gansulin-metal-peptide-pen | products | Follistatin: Reference Overview and Reconstitution Notes | references product | Gansulin Pen · Reusable Click-Dial, 3 ml (1-60 Units) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/products/gansulin-metal-peptide-pen |
| follistatin:product-gansulin-3ml-cartridge | products | Follistatin: Reference Overview and Reconstitution Notes | references product | Gansulin-Compatible 3 ml Glass Cartridge for Pens (10-Pack) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.preppinpeppers.com/products/gansulin-3ml-cartridge |
| follistatin:source-www-uniprot-org | source | Follistatin: Reference Overview and Reconstitution Notes | cites | UniProtKB P19883: Follistatin (FST, Homo sapiens), UniProt release 2026-03 - www.uniprot.org | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://www.uniprot.org/uniprotkb/P19883/entry |
| follistatin:source-pubmed-ncbi-nlm-nih-gov | source | Follistatin: Reference Overview and Reconstitution Notes | cites | Cash et al., Mol Endocrinol 2012: Characterization of follistatin-type domains and their contribution to myostatin and activin A antagonism - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://pubmed.ncbi.nlm.nih.gov/22593183/ |
| follistatin:source-pmc-ncbi-nlm-nih-gov | source | Follistatin: Reference Overview and Reconstitution Notes | cites | Bowser et al., Exp Gerontol 2013: Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells - pmc.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://pmc.ncbi.nlm.nih.gov/articles/PMC3678732/ |
| follistatin:source-pubmed-ncbi-nlm-nih-gov-2 | source | Follistatin: Reference Overview and Reconstitution Notes | cites | Patel, Int J Biochem Cell Biol 1998: Follistatin - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://pubmed.ncbi.nlm.nih.gov/9785474/ |
| follistatin:source-pmc-ncbi-nlm-nih-gov-2 | source | Follistatin: Reference Overview and Reconstitution Notes | cites | Walker et al., Exp Biol Med (Maywood) 2021: Heparin-mediated dimerization of follistatin - pmc.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://pmc.ncbi.nlm.nih.gov/articles/PMC7885052/ |
| follistatin:source-clinicaltrials-gov | source | Follistatin: Reference Overview and Reconstitution Notes | cites | ClinicalTrials.gov NCT06411366 (Phase 1, completed, first posted 2024-05-13): Phase I: Safety and Efficacy of an Injectable Follistatin Plasmid Gene Therapy in Humans - clinicaltrials.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/follistatin) | https://clinicaltrials.gov/study/NCT06411366 |

## FAQ

### What is Follistatin-344 and how does it work in research?

FST-344 is a lab-grade, lyophilized form of follistatin, a glycoprotein that binds and inhibits myostatin (GDF-8) and activin within the TGF-beta superfamily, suppressing their signaling in preclinical cell and animal models.

### How do you reconstitute Follistatin-344 for laboratory use?

Add 0.5–1 mL of bacteriostatic water to a 1 mg vial. 1 mL yields 1 mg/mL; 0.5 mL yields 2 mg/mL. Inject water slowly down the vial wall and swirl gently—never shake—until fully dissolved.

### Is follistatin banned in competitive sport?

Yes. WADA lists follistatin by name under Prohibited List category S4 (Hormone and Metabolic Modulators) because it reduces myostatin activity. It is banned both in and out of competition.

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