# KPV: Reference Overview and Reconstitution Notes - facts

Canonical page: https://www.preppinpeppers.com/blogs/the-lab/kpv
Type: Lab article

## TL;DR

KPV is a synthetic lysine-proline-valine tripeptide, the C-terminal fragment of alpha-MSH, studied in immune-signaling research. Research reference notes.

## Facts Index

| Fact ID | Category | Entity | Attribute | Value | Source | Evidence |
|---|---|---|---|---|---|---|
| kpv:title | identity | KPV: Reference Overview and Reconstitution Notes | title | KPV: Reference Overview and Reconstitution Notes | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/blogs/the-lab/kpv |
| kpv:published | identity | KPV: Reference Overview and Reconstitution Notes | published | 2026-08-15 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/blogs/the-lab/kpv |
| kpv:author | identity | KPV: Reference Overview and Reconstitution Notes | author | Preppin' Peppers Editorial Team | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/blogs/the-lab/kpv |
| kpv:topics | identity | KPV: Reference Overview and Reconstitution Notes | topics | research, Research-only | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/blogs/the-lab/kpv |
| kpv:summary | content | KPV: Reference Overview and Reconstitution Notes | summary | KPV is a synthetic lysine-proline-valine tripeptide, the C-terminal fragment of alpha-MSH, studied in immune-signaling research. Research reference notes. | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/blogs/the-lab/kpv |
| kpv:section-1 | content | KPV: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/blogs/the-lab/kpv |
| kpv:section-2 | content | KPV: Reference Overview and Reconstitution Notes | section | KPV | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/blogs/the-lab/kpv |
| kpv:section-3 | content | KPV: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/blogs/the-lab/kpv |
| kpv:section-4 | content | KPV: Reference Overview and Reconstitution Notes | section | Research context and categorization | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/blogs/the-lab/kpv |
| kpv:section-5 | content | KPV: Reference Overview and Reconstitution Notes | section | Status | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/blogs/the-lab/kpv |
| kpv:section-6 | content | KPV: Reference Overview and Reconstitution Notes | section | Reconstitution notes (general) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/blogs/the-lab/kpv |
| kpv:section-7 | content | KPV: Reference Overview and Reconstitution Notes | section | Dilution and handling notes (compound-specific) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/blogs/the-lab/kpv |
| kpv:section-8 | content | KPV: Reference Overview and Reconstitution Notes | section | Handling and storage | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/blogs/the-lab/kpv |
| kpv:section-9 | content | KPV: Reference Overview and Reconstitution Notes | section | Related reading | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/blogs/the-lab/kpv |
| kpv:section-10 | content | KPV: Reference Overview and Reconstitution Notes | section | Tools and supplies | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/blogs/the-lab/kpv |
| kpv:section-12 | content | KPV: Reference Overview and Reconstitution Notes | section | What the research community gets wrong about KPV | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/blogs/the-lab/kpv |
| kpv:product-gansulin-metal-peptide-pen | products | KPV: Reference Overview and Reconstitution Notes | references product | Gansulin Pen · Reusable Click-Dial, 3 ml (1-60 Units) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/products/gansulin-metal-peptide-pen |
| kpv:product-gansulin-3ml-cartridge | products | KPV: Reference Overview and Reconstitution Notes | references product | Gansulin-Compatible 3 ml Glass Cartridge for Pens (10-Pack) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://www.preppinpeppers.com/products/gansulin-3ml-cartridge |
| kpv:source-pubchem-ncbi-nlm-nih-gov | source | KPV: Reference Overview and Reconstitution Notes | cites | NCBI PubChem CID 125672: Msh (11-13) (C16H30N4O4) - pubchem.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://pubchem.ncbi.nlm.nih.gov/compound/125672 |
| kpv:source-pubmed-ncbi-nlm-nih-gov | source | KPV: Reference Overview and Reconstitution Notes | cites | Dalmasso et al., Gastroenterology 2008: PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://pubmed.ncbi.nlm.nih.gov/18061177/ |
| kpv:source-pubmed-ncbi-nlm-nih-gov-2 | source | KPV: Reference Overview and Reconstitution Notes | cites | Kannengiesser et al., Inflamm Bowel Dis 2008: Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://pubmed.ncbi.nlm.nih.gov/18092346/ |
| kpv:source-pubmed-ncbi-nlm-nih-gov-3 | source | KPV: Reference Overview and Reconstitution Notes | cites | Catania et al., Ann N Y Acad Sci 2000: The neuropeptide alpha-MSH in host defense - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://pubmed.ncbi.nlm.nih.gov/11268348/ |
| kpv:source-pubmed-ncbi-nlm-nih-gov-4 | source | KPV: Reference Overview and Reconstitution Notes | cites | Zhao et al., Acta Biomater 2022: A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://pubmed.ncbi.nlm.nih.gov/35245681/ |
| kpv:source-pubmed-ncbi-nlm-nih-gov-5 | source | KPV: Reference Overview and Reconstitution Notes | cites | Coutinho et al., J Sports Med Phys Fitness 2026: A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/kpv) | https://pubmed.ncbi.nlm.nih.gov/41880199/ |

## FAQ

### What is KPV peptide and where does it come from?

KPV is a synthetic tripeptide (lysine-proline-valine) derived from the C-terminal end of alpha-MSH. It is a research-only compound studied in laboratory and animal models for effects on inflammation and immune signaling. It is not FDA-approved.

### How do you reconstitute KPV lyophilized powder?

Divide the vial's milligram content by the millilitres of bacteriostatic water added to get mg/mL (e.g., 10 mg ÷ 2 mL = 5 mg/mL). KPV is water-soluble and typically dissolves at 1 mg/mL or higher without requiring acid or co-solvent.

### Is KPV prohibited by WADA anti-doping rules?

KPV is not listed by name on the WADA Prohibited List and is not classified as a melanocortin. As a substance unapproved by any health authority it may fall under the broad S0 category; athletes should treat it as potentially prohibited pending official guidance.

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