{
    "schema": 1,
    "fid": "melanotan-2",
    "type": "article",
    "object_id": 428,
    "title": "Melanotan II: Reference Overview and Reconstitution Notes",
    "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
    "url": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2",
    "facts_url": "https://www.preppinpeppers.com/facts/melanotan-2",
    "currency": null,
    "tldr": "Melanotan 2 (MT-II) is a synthetic cyclic seven-amino-acid alpha-MSH analog that activates the MC1, MC3, MC4 and MC5 receptors. Research reference notes.",
    "facts": [
        {
            "id": "melanotan-2:title",
            "category": "identity",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "title",
            "value": "Melanotan II: Reference Overview and Reconstitution Notes",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2"
        },
        {
            "id": "melanotan-2:published",
            "category": "identity",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "published",
            "value": "2026-08-15",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2"
        },
        {
            "id": "melanotan-2:author",
            "category": "identity",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "author",
            "value": "Preppin' Peppers Editorial Team",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2"
        },
        {
            "id": "melanotan-2:topics",
            "category": "identity",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "topics",
            "value": "research, Research-only",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2"
        },
        {
            "id": "melanotan-2:summary",
            "category": "content",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "summary",
            "value": "Melanotan 2 (MT-II) is a synthetic cyclic seven-amino-acid alpha-MSH analog that activates the MC1, MC3, MC4 and MC5 receptors. Research reference notes.",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2"
        },
        {
            "id": "melanotan-2:section-1",
            "category": "content",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "What it is",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2"
        },
        {
            "id": "melanotan-2:section-2",
            "category": "content",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "What it is",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2"
        },
        {
            "id": "melanotan-2:section-3",
            "category": "content",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Research context and categorization",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2"
        },
        {
            "id": "melanotan-2:section-4",
            "category": "content",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Status",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2"
        },
        {
            "id": "melanotan-2:section-5",
            "category": "content",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Reconstitution notes (general)",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2"
        },
        {
            "id": "melanotan-2:section-6",
            "category": "content",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Dilution and handling notes (compound-specific)",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2"
        },
        {
            "id": "melanotan-2:section-7",
            "category": "content",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Handling and storage",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2"
        },
        {
            "id": "melanotan-2:section-8",
            "category": "content",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Related reading",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2"
        },
        {
            "id": "melanotan-2:section-9",
            "category": "content",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Tools and supplies",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2"
        },
        {
            "id": "melanotan-2:section-11",
            "category": "content",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "What the research community gets wrong about Melanotan II",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2"
        },
        {
            "id": "melanotan-2:product-gansulin-metal-peptide-pen",
            "category": "products",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "references product",
            "value": "Gansulin Pen · Reusable Click-Dial, 3 ml (1-60 Units)",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://www.preppinpeppers.com/products/gansulin-metal-peptide-pen"
        },
        {
            "id": "melanotan-2:product-gansulin-3ml-cartridge",
            "category": "products",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "references product",
            "value": "Gansulin-Compatible 3 ml Glass Cartridge for Pens (10-Pack)",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://www.preppinpeppers.com/products/gansulin-3ml-cartridge"
        },
        {
            "id": "melanotan-2:source-pubchem-ncbi-nlm-nih-gov",
            "category": "source",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "NCBI PubChem CID 92432: melanotan-II (C50H69N15O9) - pubchem.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://pubchem.ncbi.nlm.nih.gov/compound/92432"
        },
        {
            "id": "melanotan-2:source-pubmed-ncbi-nlm-nih-gov",
            "category": "source",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "Tomassi et al., J Med Chem 2022: CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists - pubmed.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://pubmed.ncbi.nlm.nih.gov/35188390/"
        },
        {
            "id": "melanotan-2:source-pubmed-ncbi-nlm-nih-gov-2",
            "category": "source",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "Wessells et al., Int J Impot Res 2000: Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II - pubmed.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://pubmed.ncbi.nlm.nih.gov/11035391/"
        },
        {
            "id": "melanotan-2:source-pmc-ncbi-nlm-nih-gov",
            "category": "source",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "Peters et al., CEN Case Rep 2020: Melanotan II: a possible cause of renal infarction: review of the literature and case report - pmc.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7148395/"
        },
        {
            "id": "melanotan-2:source-pubmed-ncbi-nlm-nih-gov-3",
            "category": "source",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "Lan et al., J Pharm Sci 1994: Preformulation studies with melanotan-II: a potential skin cancer chemopreventive peptide - pubmed.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://pubmed.ncbi.nlm.nih.gov/7983590/"
        },
        {
            "id": "melanotan-2:source-pubmed-ncbi-nlm-nih-gov-4",
            "category": "source",
            "entity": "Melanotan II: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "Allard and Giuliano, Curr Urol Rep 2001: Central nervous system agents in the treatment of erectile dysfunction: how do they work? - pubmed.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2)",
            "evidence": "https://pubmed.ncbi.nlm.nih.gov/12084236/"
        }
    ],
    "buy": [],
    "faq": [
        {
            "q": "What is Melanotan II and how does it work?",
            "a": "Melanotan II is a synthetic 7-amino acid cyclic peptide that mimics alpha-MSH hormone and activates melanocortin receptors MC1, MC3, MC4, and MC5, influencing skin pigmentation and other signaling pathways."
        },
        {
            "q": "What is the regulatory status of Melanotan II?",
            "a": "Melanotan II is not FDA-approved for any use, classified as an investigational research substance, and is prohibited in sports under WADA S0 class (non-approved substances) at all times, in-competition and out-of-competition."
        },
        {
            "q": "How do you reconstitute Melanotan II for research?",
            "a": "Add bacteriostatic water to the lyophilized powder - a common starting point is 10mg with 2mL for a 5mg/mL stock solution, or use 3-4mL for more dilute solutions around 2.5-3.3mg/mL."
        }
    ],
    "jsonld": [
        {
            "@context": "https://schema.org",
            "@type": "Article",
            "headline": "Melanotan II: Reference Overview and Reconstitution Notes",
            "url": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2",
            "mainEntityOfPage": "https://www.preppinpeppers.com/blogs/the-lab/melanotan-2",
            "datePublished": "2026-08-15",
            "dateModified": "2026-10-16",
            "author": {
                "@type": "Person",
                "name": "Preppin' Peppers Editorial Team"
            },
            "publisher": {
                "@type": "Organization",
                "name": "PreppinPeppers"
            },
            "description": "Melanotan 2 (MT-II) is a synthetic cyclic seven-amino-acid alpha-MSH analog that activates the MC1, MC3, MC4 and MC5 receptors. Research reference notes."
        },
        {
            "@context": "https://schema.org",
            "@type": "FAQPage",
            "url": "https://www.preppinpeppers.com/facts/melanotan-2",
            "mainEntity": [
                {
                    "@type": "Question",
                    "name": "What is Melanotan II and how does it work?",
                    "acceptedAnswer": {
                        "@type": "Answer",
                        "text": "Melanotan II is a synthetic 7-amino acid cyclic peptide that mimics alpha-MSH hormone and activates melanocortin receptors MC1, MC3, MC4, and MC5, influencing skin pigmentation and other signaling pathways."
                    }
                },
                {
                    "@type": "Question",
                    "name": "What is the regulatory status of Melanotan II?",
                    "acceptedAnswer": {
                        "@type": "Answer",
                        "text": "Melanotan II is not FDA-approved for any use, classified as an investigational research substance, and is prohibited in sports under WADA S0 class (non-approved substances) at all times, in-competition and out-of-competition."
                    }
                },
                {
                    "@type": "Question",
                    "name": "How do you reconstitute Melanotan II for research?",
                    "acceptedAnswer": {
                        "@type": "Answer",
                        "text": "Add bacteriostatic water to the lyophilized powder - a common starting point is 10mg with 2mL for a 5mg/mL stock solution, or use 3-4mL for more dilute solutions around 2.5-3.3mg/mL."
                    }
                }
            ]
        }
    ],
    "dates": {
        "published": "2026-08-15",
        "modified": "2026-10-16"
    }
}