# Melanotan II: Reference Overview and Reconstitution Notes - facts

Canonical page: https://www.preppinpeppers.com/blogs/the-lab/melanotan-2
Type: Lab article

## TL;DR

Melanotan 2 (MT-II) is a synthetic cyclic seven-amino-acid alpha-MSH analog that activates the MC1, MC3, MC4 and MC5 receptors. Research reference notes.

## Facts Index

| Fact ID | Category | Entity | Attribute | Value | Source | Evidence |
|---|---|---|---|---|---|---|
| melanotan-2:title | identity | Melanotan II: Reference Overview and Reconstitution Notes | title | Melanotan II: Reference Overview and Reconstitution Notes | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://www.preppinpeppers.com/blogs/the-lab/melanotan-2 |
| melanotan-2:published | identity | Melanotan II: Reference Overview and Reconstitution Notes | published | 2026-08-15 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://www.preppinpeppers.com/blogs/the-lab/melanotan-2 |
| melanotan-2:author | identity | Melanotan II: Reference Overview and Reconstitution Notes | author | Preppin' Peppers Editorial Team | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://www.preppinpeppers.com/blogs/the-lab/melanotan-2 |
| melanotan-2:topics | identity | Melanotan II: Reference Overview and Reconstitution Notes | topics | research, Research-only | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://www.preppinpeppers.com/blogs/the-lab/melanotan-2 |
| melanotan-2:summary | content | Melanotan II: Reference Overview and Reconstitution Notes | summary | Melanotan 2 (MT-II) is a synthetic cyclic seven-amino-acid alpha-MSH analog that activates the MC1, MC3, MC4 and MC5 receptors. Research reference notes. | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://www.preppinpeppers.com/blogs/the-lab/melanotan-2 |
| melanotan-2:section-1 | content | Melanotan II: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://www.preppinpeppers.com/blogs/the-lab/melanotan-2 |
| melanotan-2:section-2 | content | Melanotan II: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://www.preppinpeppers.com/blogs/the-lab/melanotan-2 |
| melanotan-2:section-3 | content | Melanotan II: Reference Overview and Reconstitution Notes | section | Research context and categorization | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://www.preppinpeppers.com/blogs/the-lab/melanotan-2 |
| melanotan-2:section-4 | content | Melanotan II: Reference Overview and Reconstitution Notes | section | Status | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://www.preppinpeppers.com/blogs/the-lab/melanotan-2 |
| melanotan-2:section-5 | content | Melanotan II: Reference Overview and Reconstitution Notes | section | Reconstitution notes (general) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://www.preppinpeppers.com/blogs/the-lab/melanotan-2 |
| melanotan-2:section-6 | content | Melanotan II: Reference Overview and Reconstitution Notes | section | Dilution and handling notes (compound-specific) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://www.preppinpeppers.com/blogs/the-lab/melanotan-2 |
| melanotan-2:section-7 | content | Melanotan II: Reference Overview and Reconstitution Notes | section | Handling and storage | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://www.preppinpeppers.com/blogs/the-lab/melanotan-2 |
| melanotan-2:section-8 | content | Melanotan II: Reference Overview and Reconstitution Notes | section | Related reading | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://www.preppinpeppers.com/blogs/the-lab/melanotan-2 |
| melanotan-2:section-9 | content | Melanotan II: Reference Overview and Reconstitution Notes | section | Tools and supplies | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://www.preppinpeppers.com/blogs/the-lab/melanotan-2 |
| melanotan-2:section-11 | content | Melanotan II: Reference Overview and Reconstitution Notes | section | What the research community gets wrong about Melanotan II | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://www.preppinpeppers.com/blogs/the-lab/melanotan-2 |
| melanotan-2:product-gansulin-metal-peptide-pen | products | Melanotan II: Reference Overview and Reconstitution Notes | references product | Gansulin Pen · Reusable Click-Dial, 3 ml (1-60 Units) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://www.preppinpeppers.com/products/gansulin-metal-peptide-pen |
| melanotan-2:product-gansulin-3ml-cartridge | products | Melanotan II: Reference Overview and Reconstitution Notes | references product | Gansulin-Compatible 3 ml Glass Cartridge for Pens (10-Pack) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://www.preppinpeppers.com/products/gansulin-3ml-cartridge |
| melanotan-2:source-pubchem-ncbi-nlm-nih-gov | source | Melanotan II: Reference Overview and Reconstitution Notes | cites | NCBI PubChem CID 92432: melanotan-II (C50H69N15O9) - pubchem.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://pubchem.ncbi.nlm.nih.gov/compound/92432 |
| melanotan-2:source-pubmed-ncbi-nlm-nih-gov | source | Melanotan II: Reference Overview and Reconstitution Notes | cites | Tomassi et al., J Med Chem 2022: CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://pubmed.ncbi.nlm.nih.gov/35188390/ |
| melanotan-2:source-pubmed-ncbi-nlm-nih-gov-2 | source | Melanotan II: Reference Overview and Reconstitution Notes | cites | Wessells et al., Int J Impot Res 2000: Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://pubmed.ncbi.nlm.nih.gov/11035391/ |
| melanotan-2:source-pmc-ncbi-nlm-nih-gov | source | Melanotan II: Reference Overview and Reconstitution Notes | cites | Peters et al., CEN Case Rep 2020: Melanotan II: a possible cause of renal infarction: review of the literature and case report - pmc.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://pmc.ncbi.nlm.nih.gov/articles/PMC7148395/ |
| melanotan-2:source-pubmed-ncbi-nlm-nih-gov-3 | source | Melanotan II: Reference Overview and Reconstitution Notes | cites | Lan et al., J Pharm Sci 1994: Preformulation studies with melanotan-II: a potential skin cancer chemopreventive peptide - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://pubmed.ncbi.nlm.nih.gov/7983590/ |
| melanotan-2:source-pubmed-ncbi-nlm-nih-gov-4 | source | Melanotan II: Reference Overview and Reconstitution Notes | cites | Allard and Giuliano, Curr Urol Rep 2001: Central nervous system agents in the treatment of erectile dysfunction: how do they work? - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/melanotan-2) | https://pubmed.ncbi.nlm.nih.gov/12084236/ |

## FAQ

### What is Melanotan II and how does it work?

Melanotan II is a synthetic 7-amino acid cyclic peptide that mimics alpha-MSH hormone and activates melanocortin receptors MC1, MC3, MC4, and MC5, influencing skin pigmentation and other signaling pathways.

### What is the regulatory status of Melanotan II?

Melanotan II is not FDA-approved for any use, classified as an investigational research substance, and is prohibited in sports under WADA S0 class (non-approved substances) at all times, in-competition and out-of-competition.

### How do you reconstitute Melanotan II for research?

Add bacteriostatic water to the lyophilized powder - a common starting point is 10mg with 2mL for a 5mg/mL stock solution, or use 3-4mL for more dilute solutions around 2.5-3.3mg/mL.

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