{
    "schema": 1,
    "fid": "pemvidutide",
    "type": "article",
    "object_id": 452,
    "title": "Pemvidutide: Reference Overview and Reconstitution Notes",
    "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
    "url": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide",
    "facts_url": "https://www.preppinpeppers.com/facts/pemvidutide",
    "currency": null,
    "tldr": "Pemvidutide (ALT-801) is an investigational lipidated peptide from Altimmune, designed as a dual GLP-1 and glucagon receptor agonist. Reference notes.",
    "facts": [
        {
            "id": "pemvidutide:title",
            "category": "identity",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "title",
            "value": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide"
        },
        {
            "id": "pemvidutide:published",
            "category": "identity",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "published",
            "value": "2026-08-15",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide"
        },
        {
            "id": "pemvidutide:author",
            "category": "identity",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "author",
            "value": "Preppin' Peppers Editorial Team",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide"
        },
        {
            "id": "pemvidutide:topics",
            "category": "identity",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "topics",
            "value": "Investigational, research",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide"
        },
        {
            "id": "pemvidutide:summary",
            "category": "content",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "summary",
            "value": "Pemvidutide (ALT-801) is an investigational lipidated peptide from Altimmune, designed as a dual GLP-1 and glucagon receptor agonist. Reference notes.",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide"
        },
        {
            "id": "pemvidutide:section-1",
            "category": "content",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "What it is",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide"
        },
        {
            "id": "pemvidutide:section-2",
            "category": "content",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Pemvidutide",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide"
        },
        {
            "id": "pemvidutide:section-3",
            "category": "content",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "What it is",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide"
        },
        {
            "id": "pemvidutide:section-4",
            "category": "content",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Research context and categorization",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide"
        },
        {
            "id": "pemvidutide:section-5",
            "category": "content",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Status",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide"
        },
        {
            "id": "pemvidutide:section-6",
            "category": "content",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Reconstitution notes (general)",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide"
        },
        {
            "id": "pemvidutide:section-7",
            "category": "content",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Dilution and handling notes (compound-specific)",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide"
        },
        {
            "id": "pemvidutide:section-8",
            "category": "content",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Handling and storage",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide"
        },
        {
            "id": "pemvidutide:section-9",
            "category": "content",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Related reading",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide"
        },
        {
            "id": "pemvidutide:section-10",
            "category": "content",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Tools and supplies",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide"
        },
        {
            "id": "pemvidutide:section-12",
            "category": "content",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "What the research community gets wrong about pemvidutide handling",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide"
        },
        {
            "id": "pemvidutide:source-www-sec-gov",
            "category": "source",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "Altimmune results release filed with the SEC, March 2026 - www.sec.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.sec.gov/Archives/edgar/data/1326190/000132619026000013/alt-20260305xex99d1.htm"
        },
        {
            "id": "pemvidutide:product-gansulin-metal-peptide-pen",
            "category": "products",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "references product",
            "value": "Gansulin Pen · Reusable Click-Dial, 3 ml (1-60 Units)",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/products/gansulin-metal-peptide-pen"
        },
        {
            "id": "pemvidutide:product-gansulin-3ml-cartridge",
            "category": "products",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "references product",
            "value": "Gansulin-Compatible 3 ml Glass Cartridge for Pens (10-Pack)",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.preppinpeppers.com/products/gansulin-3ml-cartridge"
        },
        {
            "id": "pemvidutide:source-pubmed-ncbi-nlm-nih-gov",
            "category": "source",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "Harrison et al., J Hepatol 2025: Effect of pemvidutide, a GLP-1/glucagon dual receptor agonist, on MASLD: A randomized, double-blind, placebo-controlled study - pubmed.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://pubmed.ncbi.nlm.nih.gov/39002641/"
        },
        {
            "id": "pemvidutide:source-pmc-ncbi-nlm-nih-gov",
            "category": "source",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "Nestor et al., Sci Rep 2022: Effects of ALT-801, a GLP-1 and glucagon receptor dual agonist, in a translational mouse model of non-alcoholic steatohepatitis - pmc.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9035150/"
        },
        {
            "id": "pemvidutide:source-pubmed-ncbi-nlm-nih-gov-2",
            "category": "source",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "Rajab et al., Naunyn Schmiedebergs Arch Pharmacol 2026: Efficacy and safety of pemvidutide in metabolic dysfunction-associated steatohepatitis: a GRADE-assessed meta-analysis of randomized controlled trials - pubmed.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://pubmed.ncbi.nlm.nih.gov/41879841/"
        },
        {
            "id": "pemvidutide:source-pubmed-ncbi-nlm-nih-gov-3",
            "category": "source",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "Bailey et al., Peptides 2025: Multifunctional incretin peptides in therapies for type 2 diabetes, obesity and associated co-morbidities - pubmed.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://pubmed.ncbi.nlm.nih.gov/40081498/"
        },
        {
            "id": "pemvidutide:source-www-uniprot-org",
            "category": "source",
            "entity": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "UniProtKB P43220: Glucagon-like peptide 1 receptor (GLP1R, Homo sapiens), UniProt release 2026-03 - www.uniprot.org",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/pemvidutide)",
            "evidence": "https://www.uniprot.org/uniprotkb/P43220/entry"
        }
    ],
    "buy": [],
    "faq": [
        {
            "q": "What is pemvidutide (ALT-801) and how does it work mechanically?",
            "a": "Pemvidutide is a synthetic lipidated peptide that simultaneously activates GLP-1 and glucagon receptors (a dual agonist), targeting metabolic pathways linked to appetite signaling and hepatic fat metabolism in laboratory research."
        },
        {
            "q": "What is the regulatory and designation status of pemvidutide in 2026?",
            "a": "Pemvidutide is investigational and has not received approval from the FDA or any other regulator; it is not a licensed product. As of 2026 it holds FDA Fast Track and Breakthrough Therapy Designation for MASH and its sponsor has said it plans to start a Phase 3 trial in MASH in 2026."
        },
        {
            "q": "How do you reconstitute lyophilized pemvidutide powder for laboratory use?",
            "a": "Inject bacteriostatic water slowly down the vial wall, then gently swirl until dissolved. Calculate working concentration by dividing peptide mass (mg) by solvent volume (mL). Use aseptic technique and appropriate lab hardware throughout."
        }
    ],
    "jsonld": [
        {
            "@context": "https://schema.org",
            "@type": "Article",
            "headline": "Pemvidutide: Reference Overview and Reconstitution Notes",
            "url": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide",
            "mainEntityOfPage": "https://www.preppinpeppers.com/blogs/the-lab/pemvidutide",
            "datePublished": "2026-08-15",
            "dateModified": "2026-10-16",
            "author": {
                "@type": "Person",
                "name": "Preppin' Peppers Editorial Team"
            },
            "publisher": {
                "@type": "Organization",
                "name": "PreppinPeppers"
            },
            "description": "Pemvidutide (ALT-801) is an investigational lipidated peptide from Altimmune, designed as a dual GLP-1 and glucagon receptor agonist. Reference notes."
        },
        {
            "@context": "https://schema.org",
            "@type": "FAQPage",
            "url": "https://www.preppinpeppers.com/facts/pemvidutide",
            "mainEntity": [
                {
                    "@type": "Question",
                    "name": "What is pemvidutide (ALT-801) and how does it work mechanically?",
                    "acceptedAnswer": {
                        "@type": "Answer",
                        "text": "Pemvidutide is a synthetic lipidated peptide that simultaneously activates GLP-1 and glucagon receptors (a dual agonist), targeting metabolic pathways linked to appetite signaling and hepatic fat metabolism in laboratory research."
                    }
                },
                {
                    "@type": "Question",
                    "name": "What is the regulatory and designation status of pemvidutide in 2026?",
                    "acceptedAnswer": {
                        "@type": "Answer",
                        "text": "Pemvidutide is investigational and has not received approval from the FDA or any other regulator; it is not a licensed product. As of 2026 it holds FDA Fast Track and Breakthrough Therapy Designation for MASH and its sponsor has said it plans to start a Phase 3 trial in MASH in 2026."
                    }
                },
                {
                    "@type": "Question",
                    "name": "How do you reconstitute lyophilized pemvidutide powder for laboratory use?",
                    "acceptedAnswer": {
                        "@type": "Answer",
                        "text": "Inject bacteriostatic water slowly down the vial wall, then gently swirl until dissolved. Calculate working concentration by dividing peptide mass (mg) by solvent volume (mL). Use aseptic technique and appropriate lab hardware throughout."
                    }
                }
            ]
        }
    ],
    "dates": {
        "published": "2026-08-15",
        "modified": "2026-10-16"
    }
}