# Pinealon: Reference Overview and Reconstitution Notes - facts

Canonical page: https://www.preppinpeppers.com/blogs/the-lab/pinealon
Type: Lab article

## TL;DR

Pinealon is a synthetic tripeptide (Glu-Asp-Arg, EDR) from the Khavinson bioregulator family, referenced in cognitive-aging research. Reconstitution notes.

## Facts Index

| Fact ID | Category | Entity | Attribute | Value | Source | Evidence |
|---|---|---|---|---|---|---|
| pinealon:title | identity | Pinealon: Reference Overview and Reconstitution Notes | title | Pinealon: Reference Overview and Reconstitution Notes | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/blogs/the-lab/pinealon |
| pinealon:published | identity | Pinealon: Reference Overview and Reconstitution Notes | published | 2026-08-15 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/blogs/the-lab/pinealon |
| pinealon:last-reviewed | identity | Pinealon: Reference Overview and Reconstitution Notes | last reviewed | 2026-10-03 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/blogs/the-lab/pinealon |
| pinealon:author | identity | Pinealon: Reference Overview and Reconstitution Notes | author | Preppin' Peppers Editorial Team | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/blogs/the-lab/pinealon |
| pinealon:topics | identity | Pinealon: Reference Overview and Reconstitution Notes | topics | research, Research-only | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/blogs/the-lab/pinealon |
| pinealon:summary | content | Pinealon: Reference Overview and Reconstitution Notes | summary | Pinealon is a synthetic tripeptide (Glu-Asp-Arg, EDR) from the Khavinson bioregulator family, referenced in cognitive-aging research. Reconstitution notes. | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/blogs/the-lab/pinealon |
| pinealon:section-1 | content | Pinealon: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/blogs/the-lab/pinealon |
| pinealon:section-2 | content | Pinealon: Reference Overview and Reconstitution Notes | section | Pinealon | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/blogs/the-lab/pinealon |
| pinealon:section-3 | content | Pinealon: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/blogs/the-lab/pinealon |
| pinealon:section-4 | content | Pinealon: Reference Overview and Reconstitution Notes | section | Research context and categorization | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/blogs/the-lab/pinealon |
| pinealon:section-5 | content | Pinealon: Reference Overview and Reconstitution Notes | section | Status | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/blogs/the-lab/pinealon |
| pinealon:section-6 | content | Pinealon: Reference Overview and Reconstitution Notes | section | Reconstitution notes (general) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/blogs/the-lab/pinealon |
| pinealon:section-7 | content | Pinealon: Reference Overview and Reconstitution Notes | section | Dilution and handling notes (compound-specific) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/blogs/the-lab/pinealon |
| pinealon:section-8 | content | Pinealon: Reference Overview and Reconstitution Notes | section | Handling and storage | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/blogs/the-lab/pinealon |
| pinealon:section-9 | content | Pinealon: Reference Overview and Reconstitution Notes | section | Related reading | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/blogs/the-lab/pinealon |
| pinealon:section-10 | content | Pinealon: Reference Overview and Reconstitution Notes | section | Tools and supplies | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/blogs/the-lab/pinealon |
| pinealon:section-12 | content | Pinealon: Reference Overview and Reconstitution Notes | section | What the research community gets wrong about Pinealon handling | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/blogs/the-lab/pinealon |
| pinealon:product-gansulin-metal-peptide-pen | products | Pinealon: Reference Overview and Reconstitution Notes | references product | Gansulin Pen · Reusable Click-Dial, 3 ml (1-60 Units) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/products/gansulin-metal-peptide-pen |
| pinealon:product-gansulin-3ml-cartridge | products | Pinealon: Reference Overview and Reconstitution Notes | references product | Gansulin-Compatible 3 ml Glass Cartridge for Pens (10-Pack) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.preppinpeppers.com/products/gansulin-3ml-cartridge |
| pinealon:source-pubchem-ncbi-nlm-nih-gov | source | Pinealon: Reference Overview and Reconstitution Notes | cites | NCBI PubChem CID 10273502: Glu-Asp-Arg (C15H26N6O8) - pubchem.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://pubchem.ncbi.nlm.nih.gov/compound/10273502 |
| pinealon:source-pmc-ncbi-nlm-nih-gov | source | Pinealon: Reference Overview and Reconstitution Notes | cites | Khavinson et al., Molecules 2020: EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease - pmc.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://pmc.ncbi.nlm.nih.gov/articles/PMC7795577/ |
| pinealon:source-www-bachem-com | source | Pinealon: Reference Overview and Reconstitution Notes | cites | Bachem, Handling and Storage Guidelines for Peptides (solubility, oxidation-prone residues, storage) - www.bachem.com | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://www.bachem.com/knowledge-center/handling-and-storage-guidelines-for-peptides/ |
| pinealon:source-pubmed-ncbi-nlm-nih-gov | source | Pinealon: Reference Overview and Reconstitution Notes | cites | Khavinson et al., Rejuvenation Res 2011: Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://pubmed.ncbi.nlm.nih.gov/21978084/ |
| pinealon:source-pubmed-ncbi-nlm-nih-gov-2 | source | Pinealon: Reference Overview and Reconstitution Notes | cites | Silanteva et al., J Phys Chem B 2019: Role of Mono- and Divalent Ions in Peptide Glu-Asp-Arg-DNA Interaction - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pinealon) | https://pubmed.ncbi.nlm.nih.gov/30762356/ |

## FAQ

### What is Pinealon made of and what is its molecular weight?

Pinealon is a synthetic tripeptide composed of glutamate, aspartate, and arginine (Glu-Asp-Arg / EDR) with a molecular weight of approximately 390 g/mol. It belongs to the Khavinson bioregulator family developed in Russia.

### What research areas is Pinealon investigated for?

In cell-culture and animal models, Pinealon is investigated for neuroprotection against oxidative stress and excitotoxicity, gene expression changes in nerve cells, apoptosis reduction, and cognitive endpoints such as memory and learning.

### What is Pinealon's research and handling classification?

No. Pinealon is not FDA-approved and has no confirmed controlled clinical trials in people. It is classified strictly as a research chemical restricted to laboratory settings and is not a licensed product for people or animals.

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