# PTD-DBM: Reference Overview and Reconstitution Notes - facts

Canonical page: https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm
Type: Lab article

## TL;DR

PTD-DBM is a man-made research peptide (a short chain of amino acids built in a lab). It belongs to a group of compounds that affect a cell communication system

## Facts Index

| Fact ID | Category | Entity | Attribute | Value | Source | Evidence |
|---|---|---|---|---|---|---|
| ptd-dbm:title | identity | PTD-DBM: Reference Overview and Reconstitution Notes | title | PTD-DBM: Reference Overview and Reconstitution Notes | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm |
| ptd-dbm:published | identity | PTD-DBM: Reference Overview and Reconstitution Notes | published | 2026-08-15 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm |
| ptd-dbm:author | identity | PTD-DBM: Reference Overview and Reconstitution Notes | author | Preppin' Peppers Editorial Team | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm |
| ptd-dbm:topics | identity | PTD-DBM: Reference Overview and Reconstitution Notes | topics | research, Research-only | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm |
| ptd-dbm:summary | content | PTD-DBM: Reference Overview and Reconstitution Notes | summary | PTD-DBM is a man-made research peptide (a short chain of amino acids built in a lab). It belongs to a group of compounds that affect a cell communication system | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm |
| ptd-dbm:section-1 | content | PTD-DBM: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm |
| ptd-dbm:section-2 | content | PTD-DBM: Reference Overview and Reconstitution Notes | section | PTD-DBM | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm |
| ptd-dbm:section-3 | content | PTD-DBM: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm |
| ptd-dbm:section-4 | content | PTD-DBM: Reference Overview and Reconstitution Notes | section | Research context and categorization | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm |
| ptd-dbm:section-5 | content | PTD-DBM: Reference Overview and Reconstitution Notes | section | Status | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm |
| ptd-dbm:section-6 | content | PTD-DBM: Reference Overview and Reconstitution Notes | section | Reconstitution notes (general) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm |
| ptd-dbm:section-7 | content | PTD-DBM: Reference Overview and Reconstitution Notes | section | Dilution and handling notes (compound-specific) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm |
| ptd-dbm:section-8 | content | PTD-DBM: Reference Overview and Reconstitution Notes | section | Handling and storage | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm |
| ptd-dbm:section-9 | content | PTD-DBM: Reference Overview and Reconstitution Notes | section | Related reading | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm |
| ptd-dbm:section-10 | content | PTD-DBM: Reference Overview and Reconstitution Notes | section | Tools and supplies | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm |
| ptd-dbm:section-12 | content | PTD-DBM: Reference Overview and Reconstitution Notes | section | What the research community gets wrong about PTD-DBM | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm |
| ptd-dbm:product-gansulin-metal-peptide-pen | products | PTD-DBM: Reference Overview and Reconstitution Notes | references product | Gansulin Pen · Reusable Click-Dial, 3 ml (1-60 Units) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/products/gansulin-metal-peptide-pen |
| ptd-dbm:product-gansulin-3ml-cartridge | products | PTD-DBM: Reference Overview and Reconstitution Notes | references product | Gansulin-Compatible 3 ml Glass Cartridge for Pens (10-Pack) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://www.preppinpeppers.com/products/gansulin-3ml-cartridge |
| ptd-dbm:source-pubmed-ncbi-nlm-nih-gov | source | PTD-DBM: Reference Overview and Reconstitution Notes | cites | Lee SH et al., Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis, J Invest Dermatol 2017 (PMID 28595998) - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://pubmed.ncbi.nlm.nih.gov/28595998/ |
| ptd-dbm:source-pubmed-ncbi-nlm-nih-gov-2 | source | PTD-DBM: Reference Overview and Reconstitution Notes | cites | Ryu YC et al., CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2, Cells 2023 (PMID 36831222) - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://pubmed.ncbi.nlm.nih.gov/36831222/ |
| ptd-dbm:source-pubmed-ncbi-nlm-nih-gov-3 | source | PTD-DBM: Reference Overview and Reconstitution Notes | cites | Mehta A et al., Revolutionary Approaches to Hair Regrowth: Follicle Neogenesis, Wnt/beta-Catenin Signaling, and Emerging Therapies, Cells 2025 (PMID 40497955) - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://pubmed.ncbi.nlm.nih.gov/40497955/ |
| ptd-dbm:source-pmc-ncbi-nlm-nih-gov | source | PTD-DBM: Reference Overview and Reconstitution Notes | cites | Lee et al., J Exp Med 2015: The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing - pmc.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/ptd-dbm) | https://pmc.ncbi.nlm.nih.gov/articles/PMC4493411/ |

## FAQ

### What is PTD-DBM and how does it work in preclinical research?

PTD-DBM is a synthetic peptide pairing a protein transduction domain (PTD) with a Dishevelled binding motif (DBM). In cell and animal studies it displaces CXXC5 from the Dvl protein, removing a negative regulator of the Wnt/β-catenin signaling pathway.

### Is PTD-DBM prohibited under WADA anti-doping rules?

PTD-DBM is not listed by name on the WADA Prohibited List, but as a non-approved synthetic peptide it falls under class S0 (Non-Approved Substances), which is prohibited at all times in sport governed by WADA rules.

### How is PTD-DBM reconstituted for laboratory use?

Divide the peptide mass in the vial (mg) by the volume of bacteriostatic water added (mL) to obtain concentration. Example: 5 mg dissolved in 2 mL bacteriostatic water yields 2.5 mg/mL. Use a peptide calculator for other vial-and-volume combinations.

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