# Semax: Reference Overview and Reconstitution Notes - facts

Canonical page: https://www.preppinpeppers.com/blogs/the-lab/semax
Type: Lab article

## TL;DR

Semax is a synthetic chain of seven amino acids modeled on a fragment of the hormone ACTH. Research-only and not FDA-approved. Reference and handling notes.

## Facts Index

| Fact ID | Category | Entity | Attribute | Value | Source | Evidence |
|---|---|---|---|---|---|---|
| semax:title | identity | Semax: Reference Overview and Reconstitution Notes | title | Semax: Reference Overview and Reconstitution Notes | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/blogs/the-lab/semax |
| semax:published | identity | Semax: Reference Overview and Reconstitution Notes | published | 2026-08-15 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/blogs/the-lab/semax |
| semax:author | identity | Semax: Reference Overview and Reconstitution Notes | author | Preppin' Peppers Editorial Team | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/blogs/the-lab/semax |
| semax:topics | identity | Semax: Reference Overview and Reconstitution Notes | topics | research, Research-only | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/blogs/the-lab/semax |
| semax:summary | content | Semax: Reference Overview and Reconstitution Notes | summary | Semax is a synthetic chain of seven amino acids modeled on a fragment of the hormone ACTH. Research-only and not FDA-approved. Reference and handling notes. | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/blogs/the-lab/semax |
| semax:section-1 | content | Semax: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/blogs/the-lab/semax |
| semax:section-2 | content | Semax: Reference Overview and Reconstitution Notes | section | Semax | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/blogs/the-lab/semax |
| semax:section-3 | content | Semax: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/blogs/the-lab/semax |
| semax:section-4 | content | Semax: Reference Overview and Reconstitution Notes | section | Research context and categorization | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/blogs/the-lab/semax |
| semax:section-5 | content | Semax: Reference Overview and Reconstitution Notes | section | Status | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/blogs/the-lab/semax |
| semax:section-6 | content | Semax: Reference Overview and Reconstitution Notes | section | Reconstitution notes (general) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/blogs/the-lab/semax |
| semax:section-7 | content | Semax: Reference Overview and Reconstitution Notes | section | Dilution and handling notes (compound-specific) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/blogs/the-lab/semax |
| semax:section-8 | content | Semax: Reference Overview and Reconstitution Notes | section | Handling and storage | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/blogs/the-lab/semax |
| semax:section-9 | content | Semax: Reference Overview and Reconstitution Notes | section | Related reading | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/blogs/the-lab/semax |
| semax:section-10 | content | Semax: Reference Overview and Reconstitution Notes | section | Tools and supplies | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/blogs/the-lab/semax |
| semax:section-12 | content | Semax: Reference Overview and Reconstitution Notes | section | What the research community gets wrong about Semax | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/blogs/the-lab/semax |
| semax:product-gansulin-metal-peptide-pen | products | Semax: Reference Overview and Reconstitution Notes | references product | Gansulin Pen · Reusable Click-Dial, 3 ml (1-60 Units) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/products/gansulin-metal-peptide-pen |
| semax:product-gansulin-3ml-cartridge | products | Semax: Reference Overview and Reconstitution Notes | references product | Gansulin-Compatible 3 ml Glass Cartridge for Pens (10-Pack) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://www.preppinpeppers.com/products/gansulin-3ml-cartridge |
| semax:source-pubchem-ncbi-nlm-nih-gov | source | Semax: Reference Overview and Reconstitution Notes | cites | NCBI PubChem CID 9811102: ACTH (4-7), Pro-Gly-Pro- (C37H51N9O10S) - pubchem.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://pubchem.ncbi.nlm.nih.gov/compound/9811102 |
| semax:source-pubmed-ncbi-nlm-nih-gov | source | Semax: Reference Overview and Reconstitution Notes | cites | Panikratova et al., Dokl Biol Sci 2020: Functional Connectomic Approach to Studying Selank and Semax Effects - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://pubmed.ncbi.nlm.nih.gov/32342318/ |
| semax:source-pmc-ncbi-nlm-nih-gov | source | Semax: Reference Overview and Reconstitution Notes | cites | Mavrych et al., Front Aging 2026: Therapeutic peptides in gerontology: mechanisms and applications for healthy aging - pmc.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://pmc.ncbi.nlm.nih.gov/articles/PMC13095733/ |
| semax:source-pubmed-ncbi-nlm-nih-gov-2 | source | Semax: Reference Overview and Reconstitution Notes | cites | Glazova et al., Neuropeptides 2021: Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/semax) | https://pubmed.ncbi.nlm.nih.gov/33418449/ |

## FAQ

### What is Semax and how is it classified for research?

Semax is a synthetic seven-amino-acid peptide derived from ACTH, studied in animal models for effects on BDNF, NGF, cerebral ischemia, and cognitive outcomes. It is not FDA-approved; U.S. use is restricted to research only.

### How do researchers reconstitute lyophilized Semax powder?

Add a measured volume of bacteriostatic water to the lyophilized powder vial. Divide the milligrams of peptide by milliliters of water added to obtain concentration in mg/mL (e.g., 5 mg ÷ 5 mL = 1 mg/mL).

### Is Semax banned in competitive sport or approved as a drug anywhere?

Semax is not named on the WADA Prohibited List but may fall under the S0 catch-all category for non-approved substances. It is a registered prescription drug in Russia; that approval does not extend to the U.S. or other jurisdictions.

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