{
    "schema": 1,
    "fid": "survodutide",
    "type": "article",
    "object_id": 494,
    "title": "Survodutide: Reference Overview and Reconstitution Notes",
    "entity": "Survodutide: Reference Overview and Reconstitution Notes",
    "url": "https://www.preppinpeppers.com/blogs/the-lab/survodutide",
    "facts_url": "https://www.preppinpeppers.com/facts/survodutide",
    "currency": null,
    "tldr": "Survodutide (BI 456906) is an investigational glucagon-based peptide with a fatty acid chain, a dual glucagon and GLP-1 receptor agonist. Reference notes.",
    "facts": [
        {
            "id": "survodutide:title",
            "category": "identity",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "title",
            "value": "Survodutide: Reference Overview and Reconstitution Notes",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/survodutide"
        },
        {
            "id": "survodutide:published",
            "category": "identity",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "published",
            "value": "2026-07-10",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/survodutide"
        },
        {
            "id": "survodutide:author",
            "category": "identity",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "author",
            "value": "Preppin' Peppers Editorial Team",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/survodutide"
        },
        {
            "id": "survodutide:topics",
            "category": "identity",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "topics",
            "value": "Investigational, research",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/survodutide"
        },
        {
            "id": "survodutide:summary",
            "category": "content",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "summary",
            "value": "Survodutide (BI 456906) is an investigational glucagon-based peptide with a fatty acid chain, a dual glucagon and GLP-1 receptor agonist. Reference notes.",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/survodutide"
        },
        {
            "id": "survodutide:section-1",
            "category": "content",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "What it is",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/survodutide"
        },
        {
            "id": "survodutide:section-2",
            "category": "content",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Survodutide",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/survodutide"
        },
        {
            "id": "survodutide:section-3",
            "category": "content",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "What it is",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/survodutide"
        },
        {
            "id": "survodutide:section-4",
            "category": "content",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Research context and categorization",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/survodutide"
        },
        {
            "id": "survodutide:section-5",
            "category": "content",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Status",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/survodutide"
        },
        {
            "id": "survodutide:section-6",
            "category": "content",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Reconstitution notes (general)",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/survodutide"
        },
        {
            "id": "survodutide:section-7",
            "category": "content",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Dilution and handling notes (compound-specific)",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/survodutide"
        },
        {
            "id": "survodutide:section-8",
            "category": "content",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Handling and storage",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/survodutide"
        },
        {
            "id": "survodutide:section-9",
            "category": "content",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Related reading",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/survodutide"
        },
        {
            "id": "survodutide:section-10",
            "category": "content",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "Tools and supplies",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/survodutide"
        },
        {
            "id": "survodutide:section-12",
            "category": "content",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "section",
            "value": "What the research community gets wrong about survodutide",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/blogs/the-lab/survodutide"
        },
        {
            "id": "survodutide:product-gansulin-metal-peptide-pen",
            "category": "products",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "references product",
            "value": "Gansulin Pen · Reusable Click-Dial, 3 ml (1-60 Units)",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/products/gansulin-metal-peptide-pen"
        },
        {
            "id": "survodutide:product-gansulin-3ml-cartridge",
            "category": "products",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "references product",
            "value": "Gansulin-Compatible 3 ml Glass Cartridge for Pens (10-Pack)",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.preppinpeppers.com/products/gansulin-3ml-cartridge"
        },
        {
            "id": "survodutide:source-pubchem-ncbi-nlm-nih-gov",
            "category": "source",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "NCBI PubChem CID 168429725: Survodutide (C192H289N47O61) - pubchem.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://pubchem.ncbi.nlm.nih.gov/compound/168429725"
        },
        {
            "id": "survodutide:source-pubmed-ncbi-nlm-nih-gov",
            "category": "source",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "Sanyal et al., N Engl J Med 2024: A Phase 2 Randomized Trial of Survodutide in MASH and Fibrosis - pubmed.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://pubmed.ncbi.nlm.nih.gov/38847460/"
        },
        {
            "id": "survodutide:source-pubmed-ncbi-nlm-nih-gov-2",
            "category": "source",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "le Roux et al., Lancet Diabetes Endocrinol 2024: Glucagon and GLP-1 receptor dual agonist survodutide for obesity: a randomised, double-blind, placebo-controlled, dose-finding phase 2 trial - pubmed.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://pubmed.ncbi.nlm.nih.gov/38330987/"
        },
        {
            "id": "survodutide:source-pubmed-ncbi-nlm-nih-gov-3",
            "category": "source",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "Drucker, Diabetes Care 2024: Efficacy and Safety of GLP-1 Medicines for Type 2 Diabetes and Obesity - pubmed.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://pubmed.ncbi.nlm.nih.gov/38843460/"
        },
        {
            "id": "survodutide:source-pubmed-ncbi-nlm-nih-gov-4",
            "category": "source",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "Son et al., Endocr Rev 2026: Novel GLP-1-based Medications for Type 2 Diabetes and Obesity - pubmed.ncbi.nlm.nih.gov",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://pubmed.ncbi.nlm.nih.gov/41054801/"
        },
        {
            "id": "survodutide:source-www-uniprot-org",
            "category": "source",
            "entity": "Survodutide: Reference Overview and Reconstitution Notes",
            "attribute": "cites",
            "value": "UniProtKB/Swiss-Prot P43220: Glucagon-like peptide 1 receptor (GLP1R, Homo sapiens), UniProt release 2026-03 - www.uniprot.org",
            "source": "Lab article (https://www.preppinpeppers.com/blogs/the-lab/survodutide)",
            "evidence": "https://www.uniprot.org/uniprotkb/P43220/entry"
        }
    ],
    "buy": [],
    "faq": [
        {
            "q": "What receptors does survodutide target?",
            "a": "Survodutide is a dual agonist designed to activate both the GLP-1 receptor and the glucagon receptor (GCGR) simultaneously. Its glucagon-based structure includes an attached fatty chain that extends its duration of activity."
        },
        {
            "q": "What is the regulatory status of survodutide?",
            "a": "Survodutide is investigational and not FDA-approved for any use. It holds FDA Breakthrough Therapy designation for non-cirrhotic MASH with fibrosis, which can expedite review but is not itself an approval."
        },
        {
            "q": "How is lyophilized survodutide reconstituted for laboratory research?",
            "a": "Lyophilized survodutide powder is reconstituted by slowly introducing bacteriostatic water into the vial, gently swirling until fully dissolved, then visually inspecting for clarity and particulates before lab use."
        }
    ],
    "jsonld": [
        {
            "@context": "https://schema.org",
            "@type": "Article",
            "headline": "Survodutide: Reference Overview and Reconstitution Notes",
            "url": "https://www.preppinpeppers.com/blogs/the-lab/survodutide",
            "mainEntityOfPage": "https://www.preppinpeppers.com/blogs/the-lab/survodutide",
            "datePublished": "2026-07-10",
            "dateModified": "2026-10-16",
            "author": {
                "@type": "Person",
                "name": "Preppin' Peppers Editorial Team"
            },
            "publisher": {
                "@type": "Organization",
                "name": "PreppinPeppers"
            },
            "description": "Survodutide (BI 456906) is an investigational glucagon-based peptide with a fatty acid chain, a dual glucagon and GLP-1 receptor agonist. Reference notes."
        },
        {
            "@context": "https://schema.org",
            "@type": "FAQPage",
            "url": "https://www.preppinpeppers.com/facts/survodutide",
            "mainEntity": [
                {
                    "@type": "Question",
                    "name": "What receptors does survodutide target?",
                    "acceptedAnswer": {
                        "@type": "Answer",
                        "text": "Survodutide is a dual agonist designed to activate both the GLP-1 receptor and the glucagon receptor (GCGR) simultaneously. Its glucagon-based structure includes an attached fatty chain that extends its duration of activity."
                    }
                },
                {
                    "@type": "Question",
                    "name": "What is the regulatory status of survodutide?",
                    "acceptedAnswer": {
                        "@type": "Answer",
                        "text": "Survodutide is investigational and not FDA-approved for any use. It holds FDA Breakthrough Therapy designation for non-cirrhotic MASH with fibrosis, which can expedite review but is not itself an approval."
                    }
                },
                {
                    "@type": "Question",
                    "name": "How is lyophilized survodutide reconstituted for laboratory research?",
                    "acceptedAnswer": {
                        "@type": "Answer",
                        "text": "Lyophilized survodutide powder is reconstituted by slowly introducing bacteriostatic water into the vial, gently swirling until fully dissolved, then visually inspecting for clarity and particulates before lab use."
                    }
                }
            ]
        }
    ],
    "dates": {
        "published": "2026-07-10",
        "modified": "2026-10-16"
    }
}