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Matrixyl: Reference Overview and Reconstitution Notes
Machine-readable facts for this Lab article. The full page is https://www.preppinpeppers.com/blogs/the-lab/matrixyl.
TL;DR
Matrixyl is a family of cosmetic signal peptides, most often palmitoyl pentapeptide-4, used in skin care formulation. Reference and lab handling notes.
Facts Index
| Fact ID | Category | Entity | Attribute | Value | Source |
|---|---|---|---|---|---|
| matrixyl:title | identity | Matrixyl: Reference Overview and Reconstitution Notes | title | Matrixyl: Reference Overview and Reconstitution Notes | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:published | identity | Matrixyl: Reference Overview and Reconstitution Notes | published | 2026-08-15 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:author | identity | Matrixyl: Reference Overview and Reconstitution Notes | author | Preppin' Peppers Editorial Team | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:topics | identity | Matrixyl: Reference Overview and Reconstitution Notes | topics | research, Research-only | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:summary | content | Matrixyl: Reference Overview and Reconstitution Notes | summary | Matrixyl is a family of cosmetic signal peptides, most often palmitoyl pentapeptide-4, used in skin care formulation. Reference and lab handling notes. | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:section-1 | content | Matrixyl: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:section-2 | content | Matrixyl: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:section-3 | content | Matrixyl: Reference Overview and Reconstitution Notes | section | Research context and categorization | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:section-4 | content | Matrixyl: Reference Overview and Reconstitution Notes | section | Status | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:section-5 | content | Matrixyl: Reference Overview and Reconstitution Notes | section | Reconstitution notes (general) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:section-6 | content | Matrixyl: Reference Overview and Reconstitution Notes | section | Dilution and handling notes (compound-specific) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:section-7 | content | Matrixyl: Reference Overview and Reconstitution Notes | section | Handling and storage | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:section-8 | content | Matrixyl: Reference Overview and Reconstitution Notes | section | Related reading | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:section-9 | content | Matrixyl: Reference Overview and Reconstitution Notes | section | Tools and supplies | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:section-11 | content | Matrixyl: Reference Overview and Reconstitution Notes | section | What the research community gets wrong about Matrixyl (palmitoyl pentapeptide-4) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:product-gansulin-metal-peptide-pen | products | Matrixyl: Reference Overview and Reconstitution Notes | references product | Gansulin Pen ยท Reusable Click-Dial, 3 ml (1-60 Units) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:product-gansulin-3ml-cartridge | products | Matrixyl: Reference Overview and Reconstitution Notes | references product | Gansulin-Compatible 3 ml Glass Cartridge for Pens (10-Pack) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:source-pubchem-ncbi-nlm-nih-gov | source | Matrixyl: Reference Overview and Reconstitution Notes | cites | NCBI PubChem CID 9897237: Palmitoyl Pentapeptide-4 (C39H75N7O10) - pubchem.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:source-pubmed-ncbi-nlm-nih-gov | source | Matrixyl: Reference Overview and Reconstitution Notes | cites | Robinson et al., Int J Cosmet Sci 2005: Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:source-pubmed-ncbi-nlm-nih-gov-2 | source | Matrixyl: Reference Overview and Reconstitution Notes | cites | Choi et al., Biomol Ther (Seoul) 2014: Dermal Stability and In Vitro Skin Permeation of Collagen Pentapeptides (KTTKS and palmitoyl-KTTKS) - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:source-pubmed-ncbi-nlm-nih-gov-3 | source | Matrixyl: Reference Overview and Reconstitution Notes | cites | Osborne et al., Br J Dermatol 2012: Application of genomics to breakthroughs in the cosmetic treatment of skin ageing and discoloration - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
| matrixyl:source-pmc-ncbi-nlm-nih-gov | source | Matrixyl: Reference Overview and Reconstitution Notes | cites | de Mello et al., J Pept Sci 2026: Nanostructure and Collagen-Stimulating Activity of Cationic Pentapeptide Lipopeptides - pmc.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/matrixyl) (evidence) |
FAQ
- What is Matrixyl made of chemically?
- Matrixyl refers to palmitoyl pentapeptide-4 (Pal-KTTKS); Matrixyl 3000 pairs palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7. Each couples a short amino acid chain to a 16-carbon palmitic acid tail to aid penetration through the lipid barrier.
- Does Matrixyl need to be reconstituted with bacteriostatic water?
- No. Matrixyl is a topical cosmetic ingredient, not a freeze-dried injectable peptide. It is not supplied as a lyophilized powder requiring reconstitution and is not handled like injectable research peptides.
- What is the regulatory status of Matrixyl?
- Matrixyl is regulated as a cosmetic ingredient, reviewed by the Cosmetic Ingredient Review panel, and permitted for cosmetic use in the US and EU. It is not an FDA-approved drug for any medical use.