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PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes
Machine-readable facts for this Lab article. The full page is https://www.preppinpeppers.com/blogs/the-lab/pt-141.
TL;DR
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide and melanocortin receptor agonist that binds MC3R and MC4R receptors. Reference and handling notes.
Facts Index
| Fact ID | Category | Entity | Attribute | Value | Source |
|---|---|---|---|---|---|
| pt-141:title | identity | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | title | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:published | identity | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | published | 2026-07-10 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:author | identity | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | author | Preppin' Peppers Editorial Team | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:topics | identity | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | topics | FDA-approved, research | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:summary | content | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | summary | PT-141 (bremelanotide) is a synthetic cyclic heptapeptide and melanocortin receptor agonist that binds MC3R and MC4R receptors. Reference and handling notes. | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:section-1 | content | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:section-2 | content | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | section | PT-141 (Bremelanotide) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:section-3 | content | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:section-4 | content | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | section | Research context and categorization | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:section-5 | content | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | section | Status | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:section-6 | content | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | section | Reconstitution notes (general) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:section-7 | content | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | section | Dilution and handling notes (compound-specific) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:section-8 | content | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | section | Handling and storage | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:section-9 | content | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | section | Related reading | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:section-10 | content | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | section | Tools and supplies | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:section-12 | content | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | section | What the research community gets wrong about PT-141 (Bremelanotide) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:product-gansulin-metal-peptide-pen | products | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | references product | Gansulin Pen ยท Reusable Click-Dial, 3 ml (1-60 Units) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:product-gansulin-3ml-cartridge | products | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | references product | Gansulin-Compatible 3 ml Glass Cartridge for Pens (10-Pack) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:source-pubchem-ncbi-nlm-nih-gov | source | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | cites | NCBI PubChem CID 9941379: Bremelanotide (C50H68N14O10) - pubchem.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:source-dailymed-nlm-nih-gov | source | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | cites | DailyMed: VYLEESI (bremelanotide) injection label, FDA/NLM - dailymed.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:source-pubmed-ncbi-nlm-nih-gov | source | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | cites | Kingsberg et al., Obstet Gynecol 2019: Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:source-pubmed-ncbi-nlm-nih-gov-2 | source | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | cites | Dhillon and Keam, Drugs 2019: Bremelanotide: First Approval - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:source-pubmed-ncbi-nlm-nih-gov-3 | source | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | cites | Clayton et al., J Womens Health (Larchmt) 2022: Safety Profile of Bremelanotide Across the Clinical Development Program - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
| pt-141:source-pmc-ncbi-nlm-nih-gov | source | PT-141 (Bremelanotide): Reference Overview and Reconstitution Notes | cites | Edinoff et al., Neurol Int 2022: Bremelanotide for Treatment of Female Hypoactive Sexual Desire - pmc.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/pt-141) (evidence) |
FAQ
- What receptors does PT-141 (bremelanotide) bind to?
- PT-141 is a melanocortin receptor agonist that binds MC3R and MC4R, receptor proteins in the brain linked to central pathways studied in arousal and desire research.
- Is bremelanotide FDA approved?
- Yes. Bremelanotide is FDA-approved as Vyleesi for acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. All other uses are off-label or investigational.
- How do you reconstitute PT-141 lyophilized powder for research?
- Add bacteriostatic water to the vial and divide the vial's milligrams by the milliliters of water added to get concentration in mg/mL. Example: 10 mg + 2 mL = 5 mg/mL.