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SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes
Machine-readable facts for this Lab article. The full page is https://www.preppinpeppers.com/blogs/the-lab/snap-8.
TL;DR
SNAP-8 (Acetyl Octapeptide-3) is a synthetic cosmetic peptide of eight amino acids with an acetyl group, studied in skin research. Not an FDA-approved drug.
Facts Index
| Fact ID | Category | Entity | Attribute | Value | Source |
|---|---|---|---|---|---|
| snap-8:title | identity | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | title | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:published | identity | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | published | 2026-08-15 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:last-reviewed | identity | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | last reviewed | 2026-10-03 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:author | identity | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | author | Preppin' Peppers Editorial Team | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:topics | identity | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | topics | research, Research-only | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:summary | content | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | summary | SNAP-8 (Acetyl Octapeptide-3) is a synthetic cosmetic peptide of eight amino acids with an acetyl group, studied in skin research. Not an FDA-approved drug. | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:section-1 | content | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:section-2 | content | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | section | SNAP-8 (Acetyl Octapeptide-3) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:section-3 | content | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:section-4 | content | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | section | Research context and categorization | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:section-5 | content | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | section | Status | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:section-6 | content | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | section | Reconstitution notes (general) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:section-7 | content | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | section | Dilution and handling notes (compound-specific) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:section-8 | content | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | section | Handling and storage | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:section-9 | content | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | section | Related reading | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:section-10 | content | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | section | Tools and supplies | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:section-12 | content | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | section | What the research community gets wrong about SNAP-8 (Acetyl Octapeptide-3) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:product-gansulin-metal-peptide-pen | products | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | references product | Gansulin Pen ยท Reusable Click-Dial, 3 ml (1-60 Units) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:product-gansulin-3ml-cartridge | products | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | references product | Gansulin-Compatible 3 ml Glass Cartridge for Pens (10-Pack) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:source-pubchem-ncbi-nlm-nih-gov | source | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | cites | NCBI PubChem CID 71587832: Acetyl octapeptide-3 (C42H72N16O15S) - pubchem.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:source-pubmed-ncbi-nlm-nih-gov | source | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | cites | Shin et al., Ann Dermatol 2024: Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
| snap-8:source-pubmed-ncbi-nlm-nih-gov-2 | source | SNAP-8 (Acetyl Octapeptide-3): Reference Overview and Reconstitution Notes | cites | Avcil et al., J Cosmet Dermatol 2020: Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/snap-8) (evidence) |
FAQ
- What is SNAP-8 (Acetyl Octapeptide-3) and how does it differ from Argireline (Acetyl Hexapeptide-3)?
- SNAP-8 is a synthetic octapeptide (CAS 868844-74-0) with an N-terminal acetyl group. It extends Argireline by two amino acids and is studied for analogous SNARE-complex modulation in topical cosmetic-formulation research.
- How does SNAP-8 interact with the SNARE protein complex at the cellular level?
- SNAP-8 mimics a region of SNAP-25, a core SNARE-complex protein. Researchers investigate whether it competitively occupies that site, potentially attenuating acetylcholine release at nerve-muscle junctions and reducing contraction-linked expression lines.
- Is SNAP-8 FDA-approved, and does it appear on the WADA Prohibited List?
- No. SNAP-8 is not FDA-approved for any therapeutic use and is classified as a cosmetic ingredient. It is not named on the WADA Prohibited List, as it has no recognized systemic or performance-enhancing action.