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TB-500: Reference Overview and Reconstitution Notes
Machine-readable facts for this Lab article. The full page is https://www.preppinpeppers.com/blogs/the-lab/tb-500.
TL;DR
TB-500 is a man-made heptapeptide, a seven-amino-acid fragment of thymosin beta-4 studied in tissue-repair research. Overview and reconstitution notes.
Facts Index
| Fact ID | Category | Entity | Attribute | Value | Source |
|---|---|---|---|---|---|
| tb-500:title | identity | TB-500: Reference Overview and Reconstitution Notes | title | TB-500: Reference Overview and Reconstitution Notes | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:published | identity | TB-500: Reference Overview and Reconstitution Notes | published | 2026-07-10 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:author | identity | TB-500: Reference Overview and Reconstitution Notes | author | Preppin' Peppers Editorial Team | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:topics | identity | TB-500: Reference Overview and Reconstitution Notes | topics | research, Research-only | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:summary | content | TB-500: Reference Overview and Reconstitution Notes | summary | TB-500 is a man-made heptapeptide, a seven-amino-acid fragment of thymosin beta-4 studied in tissue-repair research. Overview and reconstitution notes. | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:section-1 | content | TB-500: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:section-2 | content | TB-500: Reference Overview and Reconstitution Notes | section | TB-500 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:section-3 | content | TB-500: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:section-4 | content | TB-500: Reference Overview and Reconstitution Notes | section | Research context and categorization | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:section-5 | content | TB-500: Reference Overview and Reconstitution Notes | section | Status | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:section-6 | content | TB-500: Reference Overview and Reconstitution Notes | section | Reconstitution notes (general) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:section-7 | content | TB-500: Reference Overview and Reconstitution Notes | section | Dilution and handling notes (compound-specific) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:section-8 | content | TB-500: Reference Overview and Reconstitution Notes | section | Handling and storage | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:section-9 | content | TB-500: Reference Overview and Reconstitution Notes | section | Related reading | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:section-10 | content | TB-500: Reference Overview and Reconstitution Notes | section | Tools and supplies | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:section-12 | content | TB-500: Reference Overview and Reconstitution Notes | section | What the research community gets wrong about TB-500 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:product-gansulin-metal-peptide-pen | products | TB-500: Reference Overview and Reconstitution Notes | references product | Gansulin Pen · Reusable Click-Dial, 3 ml (1-60 Units) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:product-gansulin-3ml-cartridge | products | TB-500: Reference Overview and Reconstitution Notes | references product | Gansulin-Compatible 3 ml Glass Cartridge for Pens (10-Pack) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:source-pubchem-ncbi-nlm-nih-gov | source | TB-500: Reference Overview and Reconstitution Notes | cites | NCBI PubChem CID 62707662: TB 500 acetate (C38H68N10O14) - pubchem.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:source-www-uniprot-org | source | TB-500: Reference Overview and Reconstitution Notes | cites | UniProtKB P62328: Thymosin beta-4 (TMSB4X, Homo sapiens), UniProt release 2026-03 - www.uniprot.org | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:source-pubmed-ncbi-nlm-nih-gov | source | TB-500: Reference Overview and Reconstitution Notes | cites | Sun and Yin, Ann N Y Acad Sci 2007: The beta-thymosin enigma - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:source-pmc-ncbi-nlm-nih-gov | source | TB-500: Reference Overview and Reconstitution Notes | cites | Zeng et al., Stem Cell Reports 2025: Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoids - pmc.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:source-pubmed-ncbi-nlm-nih-gov-2 | source | TB-500: Reference Overview and Reconstitution Notes | cites | Mayfield et al., Am J Sports Med 2026: Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
| tb-500:source-clinicaltrials-gov | source | TB-500: Reference Overview and Reconstitution Notes | cites | ClinicalTrials.gov NCT07487363 (Phase 1, Phase 2, recruiting, first posted 2026-03-23): TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVD - clinicaltrials.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/tb-500) (evidence) |
FAQ
- What is the difference between TB-500 and thymosin beta-4?
- Thymosin beta-4 is a full 43-amino-acid protein; TB-500 is a synthetic 7-amino-acid fragment (residues 17–23) derived from it. The two are chemically distinct, though product listings often conflate them.
- How do you reconstitute TB-500 lyophilized powder for lab use?
- Add bacteriostatic water to the vial and divide mg of peptide by mL of water added to get concentration. For example, 5 mg + 2 mL = 2.5 mg/mL. Swirl gently; do not shake.
- Is TB-500 banned in sport?
- Yes. WADA lists thymosin beta-4 and related fragments, including TB-500, on its Prohibited List under growth factors and growth factor modulators, banned at all times in and out of competition.