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Epitalon: Reference Overview and Reconstitution Notes
Machine-readable facts for this Lab article. The full page is https://www.preppinpeppers.com/blogs/the-lab/epitalon.
TL;DR
Epitalon is a synthetic pineal-derived tetrapeptide of the Khavinson bioregulator family, studied in longevity research. Not FDA-approved; reconstitution notes.
Facts Index
| Fact ID | Category | Entity | Attribute | Value | Source |
|---|---|---|---|---|---|
| epitalon:title | identity | Epitalon: Reference Overview and Reconstitution Notes | title | Epitalon: Reference Overview and Reconstitution Notes | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:published | identity | Epitalon: Reference Overview and Reconstitution Notes | published | 2026-08-15 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:last-reviewed | identity | Epitalon: Reference Overview and Reconstitution Notes | last reviewed | 2026-10-03 | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:author | identity | Epitalon: Reference Overview and Reconstitution Notes | author | Preppin' Peppers Editorial Team | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:topics | identity | Epitalon: Reference Overview and Reconstitution Notes | topics | research, Research-only | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:summary | content | Epitalon: Reference Overview and Reconstitution Notes | summary | Epitalon is a synthetic pineal-derived tetrapeptide of the Khavinson bioregulator family, studied in longevity research. Not FDA-approved; reconstitution notes. | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:section-1 | content | Epitalon: Reference Overview and Reconstitution Notes | section | Epitalon | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:section-2 | content | Epitalon: Reference Overview and Reconstitution Notes | section | What it is | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:section-3 | content | Epitalon: Reference Overview and Reconstitution Notes | section | Research context and categorization | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:section-4 | content | Epitalon: Reference Overview and Reconstitution Notes | section | Status | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:section-5 | content | Epitalon: Reference Overview and Reconstitution Notes | section | Reconstitution notes (general) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:section-6 | content | Epitalon: Reference Overview and Reconstitution Notes | section | Dilution and handling notes (compound-specific) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:section-7 | content | Epitalon: Reference Overview and Reconstitution Notes | section | Handling and storage | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:section-8 | content | Epitalon: Reference Overview and Reconstitution Notes | section | Related reading | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:section-9 | content | Epitalon: Reference Overview and Reconstitution Notes | section | Tools and supplies | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:section-11 | content | Epitalon: Reference Overview and Reconstitution Notes | section | What the research community gets wrong about Epitalon handling | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:product-gansulin-metal-peptide-pen | products | Epitalon: Reference Overview and Reconstitution Notes | references product | Gansulin Pen ยท Reusable Click-Dial, 3 ml (1-60 Units) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:product-gansulin-3ml-cartridge | products | Epitalon: Reference Overview and Reconstitution Notes | references product | Gansulin-Compatible 3 ml Glass Cartridge for Pens (10-Pack) | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:source-pubchem-ncbi-nlm-nih-gov | source | Epitalon: Reference Overview and Reconstitution Notes | cites | NCBI PubChem CID 219042: Epitalon (C14H22N4O9) - pubchem.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:source-pubmed-ncbi-nlm-nih-gov | source | Epitalon: Reference Overview and Reconstitution Notes | cites | Araj et al., Int J Mol Sci 2025: Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:source-pubmed-ncbi-nlm-nih-gov-2 | source | Epitalon: Reference Overview and Reconstitution Notes | cites | Sibarov et al., Neuro Endocrinol Lett 2002: Epitalon influences pineal secretion in stress-exposed rats in the daytime - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:source-pubmed-ncbi-nlm-nih-gov-3 | source | Epitalon: Reference Overview and Reconstitution Notes | cites | Khavinson VKh, Neuro Endocrinol Lett 2002: Peptides and Ageing - pubmed.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
| epitalon:source-pmc-ncbi-nlm-nih-gov | source | Epitalon: Reference Overview and Reconstitution Notes | cites | Yue et al., Aging (Albany NY) 2022: Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro - pmc.ncbi.nlm.nih.gov | Lab article (https://www.preppinpeppers.com/blogs/the-lab/epitalon) (evidence) |
FAQ
- What is Epitalon and what is its amino acid sequence?
- Epitalon (also Epithalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG) and a molecular weight of ~390 g/mol, designed to mimic epithalamin, a longer protein derived from the pineal gland.
- Is Epitalon FDA-approved, and what is its regulatory status as of 2026?
- No. Epitalon has no FDA-approved use, is classified as a research chemical not for human consumption, and as of 2026 was removed from the FDA 503A compounding category and placed under formal advisory review.
- What is Epitalon studied for in laboratory and animal research?
- It is studied in cell and animal models for telomerase activation, telomere elongation, melatonin regulation, antioxidant activity, and lifespan endpoints. No controlled human clinical trial has confirmed these effects.