Livagen
What it is
Livagen is a synthetic short-peptide bioregulator of the Khavinson class, described as the tetrapeptide Lys-Glu-Asp-Ala (often abbreviated KEDA). It is one of the small tissue-peptide bioregulators associated with the Saint Petersburg Institute of Bioregulation and Gerontology, and this is a neutral reference entry covering identity, regulatory status, and handling only.
Research context and categorization
Livagen is grouped with the Khavinson bioregulators, a family of short peptides discussed in the anti-aging and longevity category, with a particular focus on the liver and on immune-related tissue. In that framework the compound is commonly discussed in relation to hepatic (liver) tissue, and it is investigated for a proposed interaction with chromatin and gene expression, including reported de-heterochromatinization in lymphocytes from older donors and activation of ribosomal genes in laboratory settings. It has also been studied in the context of preclinical models of liver injury and immune function. All of these uses are investigational. Livagen is not FDA-approved, the described effects come largely from Russian preclinical work with limited independent replication, and none should be read as confirmed or approved benefits.
Status
- Regulatory status: Research-only. Livagen is not FDA-approved and has no approved human or veterinary indication. It is characterized largely in preclinical work with no established human clinical trials, and it is supplied as a research chemical rather than a drug, food, cosmetic, or dietary supplement.
- Sport status: Not specifically listed on the WADA Prohibited List by name. Note that WADA can still capture substances by pharmacological class and through its catch-all for compounds with similar chemical structure or biological effect, so the absence of a specific listing does not by itself mean a substance is permitted in competition.
Reconstitution notes (general)
Livagen typically ships as a lyophilized (freeze-dried) powder that is reconstituted with bacteriostatic water before laboratory use. The working concentration is simply the milligrams of peptide in the vial divided by the millilitres of bacteriostatic water added. For example, a 20 mg vial brought up with 2 mL of water yields 10 mg per mL, while the same vial with 3 mL yields about 6.7 mg per mL. To plan a target concentration, use the reconstitution calculator at our reconstitution and blend calculators.
Dilution and handling notes (compound-specific)
Livagen is a very small molecule, a tetrapeptide of only four amino acids, and short Khavinson-class peptides like this are highly water-soluble. In practice it tends to go into solution readily and cleanly, giving a clear, colorless liquid without the gelling, clouding, or stringiness sometimes seen with larger or more hydrophobic peptides. The charged, hydrophilic side chains of lysine, glutamic acid, and aspartic acid help it dissolve without heating or vortexing.
Livagen is commonly sold in small vials, often in the 10 mg to 20 mg range, and typical reconstitution volumes fall in the range of roughly 2 to 3 mL of bacteriostatic water per vial, which puts working concentrations in a convenient band of about 6.7 to 10 mg per mL. The exact volume is a matter of the desired concentration rather than a solubility limit; a round number like 10 mg per mL is chosen mainly to make measurement simpler, not because the peptide requires it.
Handling quirks worth noting: - Add the water slowly and let it run down the inside wall of the vial rather than injecting it forcefully onto the powder cake. Aggressive squirting can foam the solution, and short peptides do not need agitation to dissolve. - Do not shake. Swirl gently or simply let the vial sit for a minute or two, and the powder should clear on its own. Foaming at the air-liquid interface makes accurate measurement harder and can stress the peptide. - If a faint haze remains immediately after adding water, a short rest at room temperature usually resolves it as the last of the powder finishes dissolving. Powder that will not clear, or a solution that turns cloudy later, is a signal to discard rather than force back into solution. - Keep the vial out of direct light during handling, avoid repeated freeze-thaw cycles of the mixed solution, and return it to refrigeration promptly.
Handling and storage
Store the lyophilized powder cold, and keep the reconstituted vial refrigerated at 2 to 8 degrees Celsius. Keep it out of light. Wipe the rubber stopper with an alcohol swab before each puncture, and label the vial with the date it was mixed. Observe the general working window of about four weeks under refrigeration for a reconstituted vial. Discard anything that becomes cloudy, discolored, or shows floating particles.
Related reading
Tools and supplies
- Reconstitution & blend calculators
- Bacteriostatic Water 30 ml
- Gansulin Metal Reusable Pen
- 3 ml Glass Cartridges (10-pack)
- Complete Starter Kit
For laboratory and research reference only. Educational content, not medical, dosing, injection, or therapeutic guidance, and not intended for human or animal use. Any research uses described are investigational and not confirmed or approved benefits. Confirm anything involving health with a licensed professional. References linked above.