Prostamax: Reference Overview and Reconstitution Notes

Prostamax is a small, man-made protein fragment called a peptide bioregulator. It is linked to prostate tissue research and belongs to the Khavinson family of compounds. It is studied as a research-only compound and is not FDA-approved.

What it is

Prostamax is a small, man-made protein fragment. Protein fragments like this are called peptides. It is also called a bioregulator, meaning it is studied for how it may influence tissue behavior in the lab. It belongs to the Khavinson family, a group of similar short peptides first researched by a Russian scientist named Khavinson.

Prostamax has a fixed order of four building blocks called amino acids: Lys-Glu-Asp-Pro. Think of those four letters as a very short instruction written in the language of proteins. It was designed as a cleaner, lab-made replacement for older extracts taken from cow (bovine) prostate tissue, such as Prostatilen and Vitaprost.

Research context and categorization

Prostamax belongs to the Khavinson bioregulator group. Researchers study this family of peptides for possible connections to how genes turn on or off in specific tissues, a process called tissue-specific gene expression. They also study these compounds in the context of aging and longevity research. Within this family, Prostamax is the compound linked to prostate tissue.

Research on Prostamax uses preclinical models. These are lab experiments (such as cell studies or animal studies) done before any human testing. The work looks at age-related changes in prostate tissue. Scientists study it in connection with tissue repair and inflammatory signaling in prostate tissue. Inflammatory signaling means the chemical messages tissue sends when it is irritated or under stress. It is also studied for how it may affect epigenetic control of genes. Epigenetic changes affect how genes are read without changing the DNA itself. Think of it like adjusting the volume on a song without rewriting the lyrics. This is different from how most drugs work, which is by fitting into a specific protein like a key in a lock. Researchers have also looked at it for questions about aging in glandular and reproductive tissue, in laboratory settings.

All of these uses are investigational, meaning they are still being studied and not proven. Prostamax is not FDA-approved. Most of the research comes from one institute, and other labs have not widely repeated the results. There are no large, carefully controlled Western research trials (called randomized controlled trials) for this compound. Any effects described in the literature should be treated as unconfirmed.

Key point: Prostamax is an investigational compound that is not FDA-approved. Research so far is limited to preclinical models and comes mainly from a single originating institute.

Status

• Regulatory status: Research-only and not FDA-approved. Prostamax has not been evaluated or approved as a medicine for human or veterinary use by the FDA, EMA, or similar agencies.
• Sport status: Not specifically listed on the WADA Prohibited List. WADA is the World Anti-Doping Agency. Prostamax is not named on their list. As a short prostate-linked bioregulator, it does not fall under the named growth-factor or peptide-hormone entries. Note that WADA can treat an unlisted substance with a similar structure or biological effect as prohibited. This means the compound is not explicitly named, not that it has received formal clearance.

Reconstitution notes (general)

Concentration is how much compound is packed into each milliliter of liquid. You find it by dividing the milligrams (mg) of compound in the vial by the milliliters (mL) of water you add. For example, a 20 mg vial mixed with 2 mL of bacteriostatic water gives 10 mg/mL. The same vial mixed with 4 mL gives 5 mg/mL. You can work out these numbers with the peptide calculator.

Dilution and handling notes (compound-specific)

Prostamax comes as a lyophilized (freeze-dried) powder, usually in a 20 mg vial. It must be mixed with liquid before lab use. A common approach is to add about 2 to 4 mL of bacteriostatic water to a 20 mg vial. This puts the working concentration in a convenient range.

Using more water makes it easier to draw small volumes accurately. That is a practical reason, not a chemical one. Bacteriostatic water is the standard mixing liquid. It contains a small amount of benzyl alcohol, which slows the growth of bacteria. This allows the vial to be accessed more than once while staying safe for lab work.

Chemical Characteristics and Solubility

Prostamax is a very small, charged peptide that is water-loving (called hydrophilic). Its molecular weight is about 487 Da (daltons, a unit used to measure the mass of tiny molecules), and its formula is C20H33N5O9. Because it is drawn to water, it dissolves easily in sterile or bacteriostatic water. It usually forms a clear, colorless liquid without needing heat or hard mixing.

Clouding, gelling, or solid particles settling at the bottom are not normal problems with Prostamax. It does not usually need extra dilution steps to dissolve. It does not dissolve well in oily or non-polar solvents, so water-based liquids (called aqueous diluents) are the right choice.

Reconstitution Steps and Mechanical Handling

The main things to watch when preparing Prostamax are physical, not chemical. Follow these steps for best results:

1. Let the sealed vial and the liquid reach room temperature first. This helps prevent a brief cloudiness when the water is added.
2. Add the water slowly, aiming the stream down the inside wall of the vial rather than directly onto the powder. This reduces foaming.
3. Mix by gentle swirling or rolling. Do not shake hard, as vigorous shaking can create foam.
4. Keep the peptide away from direct light during preparation and storage, as it is reported to be light-sensitive.

A correctly prepared solution should look completely clear and colorless.

Handling and storage

Follow these steps to keep the compound stable:

• Store the reconstituted vial in the refrigerator at 2 to 8 degrees Celsius and keep it away from light.
• Wipe the rubber stopper with an alcohol swab before each puncture.
• Write the mixing date on the vial so you know how old it is. The general working window is about four weeks when kept refrigerated.
• Do not let the vial go through freeze-thaw cycles once it has been mixed.
• Discard any solution that turns cloudy, changes color, or shows visible particles or floaters.

Related reading

• PTD-DBM
• Selank
• Semax
• How Reconstitution Works
• How Long Does a Reconstituted Vial Last?

Tools and supplies

• peptide calculator
• Bacteriostatic Water 30 ml
• Gansulin Metal Reusable Pen
• 3 ml Glass Cartridges (10-pack)
• Complete Starter Kit

Reminder: research and educational reference only. Preppin Peppers sells hardware and materials, not peptides. Not medical, dosing, or health advice, not evaluated by the FDA, and not intended for human or animal use.

Frequently asked questions

What is the amino acid sequence of Prostamax?

Prostamax is a tetrapeptide with the fixed sequence Lys-Glu-Asp-Pro. It is a synthetic compound developed as a lab-made alternative to bovine prostate extracts such as Prostatilen and Vitaprost.

Is Prostamax FDA-approved or listed on the WADA Prohibited List?

Prostamax is not FDA-approved for human or veterinary use. It is not explicitly named on the WADA Prohibited List, though WADA may still treat unlisted compounds with similar structure or biological effect as prohibited.

What research areas is Prostamax investigated in?

Preclinical studies examine Prostamax in the context of prostate tissue biology, epigenetic gene regulation, inflammatory signaling, and age-related glandular changes. Most published work originates from one institute; large controlled trials are absent.

What the research community gets wrong about Prostamax

A few ideas about this tetrapeptide (Lys-Glu-Asp-Pro) come up again and again at the bench. Most of them mix up what the literature actually shows with what people assume it shows.

• "Bioregulator" does not mean proven. The word just names a research category. The published work on Prostamax is mostly preclinical (cell and animal models) and comes mainly from a single originating institute, so treat any described effect as unconfirmed rather than established.
• It is not the same as the old prostate extracts. People lump Prostamax together with bovine (cow) prostate extracts like Prostatilen and Vitaprost. Prostamax is a defined, lab-made four amino acid sequence, not a crude tissue extract, so results from those older materials do not automatically carry over.
• It is not studied as a typical lock-and-key drug. Reviews of this peptide family describe short peptides being studied for possible effects on gene expression (epigenetic regulation), which is a different proposed idea than a molecule fitting a single receptor. That mechanism is still investigational, not settled science.
• "Not on the WADA list" is not the same as cleared. Prostamax is not explicitly named, but WADA can treat an unlisted compound with a similar structure or effect as prohibited. Not named is not the same as approved or reviewed.
• Dissolving it is a physical task, not a chemistry problem. Because it is small and water-loving (hydrophilic), it goes into bacteriostatic water with gentle swirling and does not need heat or hard shaking. Foaming or brief cloudiness comes from rough handling, not from the peptide being hard to dissolve.

From our bench: If you reconstitute a 20 mg vial of Prostamax, we want your real handling notes. Time how long it takes to go fully clear with gentle swirling, note the water volume you added, and record whether the solution stays clear and colorless as it sits refrigerated over its working window. Send us your actual observations (including any cloudiness or particles you see), not estimates, and we will add verified bench notes here with credit.

Sources

1. Bacteriostatic Water for Injection, USP , FDA/DailyMed label (0.9% benzyl alcohol)
2. Duerkop et al., Biotechnol J 2018 , Impact of Cavitation, High Shear Stress and Air/Liquid Interfaces on Protein Aggregation
3. Sigma-Aldrich (Merck) , Handling and Storage Guidelines for Peptides and Proteins
4. Khavinson VK et al., Peptide Regulation of Gene Expression: A Systematic Review, Molecules 2021 (PMID 34834147)
5. Khavinson V et al., Peptide Regulation of Cell Differentiation, Stem Cell Rev Rep 2020 (PMID 31808038)
6. Khavinson VKh, Peptides and Ageing, Neuro Endocrinol Lett 2002 (PMID 12374906)