Amycretin
What it is
Amycretin, also referenced by the development code NN9487, is a peptide-based, single-molecule (unimolecular) agonist that acts at both the GLP-1 receptor and the amylin receptor. It is being developed in two presentations, a subcutaneous form and an oral form.
Research context and categorization
Amycretin falls under the metabolic and weight regulation category. Both of its targets, the GLP-1 receptor and the amylin receptor, are associated with appetite signaling and energy metabolism, which is why a molecule combining the two is grouped here rather than with growth-hormone secretagogues or tissue-repair peptides.
In published work it is studied in the context of body weight reduction and glycemic measures such as HbA1c, and it is commonly discussed in relation to how a dual GLP-1 and amylin mechanism might compare with single-target GLP-1 approaches. These uses are investigational. Amycretin has not been approved for any indication, and the outcomes described in early-phase and phase 2 studies are not confirmed or established benefits.
Status
- Regulatory status: Investigational, not FDA-approved. As of mid-2026 it has been reported through early-phase and phase 2 studies with a phase 3 program planned, and it has no approved indication, no prescribing route, and no compounding pathway.
- Sport status: Prohibited under the WADA Prohibited List. As a substance without current regulatory approval for human therapeutic use it falls under S0 (Non-Approved Substances), and as a peptide hormone agonist acting at hormone receptors it is closely related to the S2 class (Peptide Hormones, Growth Factors, Related Substances and Mimetics). Athletes subject to WADA or USADA rules should treat it as banned.
Reconstitution notes (general)
For a lyophilized (freeze-dried) research peptide supplied as a powder, concentration equals the milligrams of peptide in the vial divided by the millilitres of bacteriostatic water added. For example, 10 mg of powder plus 2 mL of bacteriostatic water gives a solution at 5 mg/mL. Add the water slowly down the inner wall of the vial rather than spraying it onto the powder, then swirl or gently roll until dissolved. You can work out volumes with the calculator at our reconstitution and blend calculators.
Dilution and handling notes (compound-specific)
Amycretin appears in two forms, and they are handled differently. The oral form is a solid, tablet-style dose. It is not reconstituted at all and involves no bacteriostatic water step, so a lyophilized powder presentation is the only form these notes apply to. Do not attempt to dissolve an oral unit as if it were an injectable.
The practically important quirk of a powder presentation comes from the amylin half of the molecule. Amylin and its analogs are amyloidogenic, meaning the peptide has a documented tendency to self-associate and aggregate. In solution this can show up as clouding, a gel-like or stringy consistency, or fine precipitate, and the risk rises as concentration increases and as the solution sits. The common practical response is to keep the reconstituted concentration on the more dilute side rather than packing a large mass into a minimal volume of water, which is why a fuller volume of diluent per vial is often preferred over the smallest possible amount. Add the diluent slowly against the glass, swirl gently, and do not shake, since agitation and foaming can seed aggregation. A brief rest at room temperature to allow full dissolution before refrigerating is typical. If the material gels, clouds persistently, or throws visible particles that do not clear with gentle mixing over several minutes, it should not be used. As with other peptides, protect it from light and avoid repeated warming and cooling cycles.
Handling and storage
Store reconstituted solution refrigerated at 2 to 8 C and keep it out of light. Wipe the rubber stopper with an alcohol swab before each access, and label the vial with the mix date. Observe the general refrigerated window of roughly four weeks for a reconstituted peptide. Discard anything that has turned cloudy or discolored, or that shows floaters or particulate matter.
Related reading
Tools and supplies
- Reconstitution & blend calculators
- Bacteriostatic Water 30 ml
- Gansulin Metal Reusable Pen
- 3 ml Glass Cartridges (10-pack)
- Complete Starter Kit
For laboratory and research reference only. Educational content, not medical, dosing, injection, or therapeutic guidance, and not intended for human or animal use. Any research uses described are investigational and not confirmed or approved benefits. Confirm anything involving health with a licensed professional. References linked above.