Cagrilintide
What it is
Cagrilintide (also referenced as AM833) is a synthetic, long-acting amylin analog peptide. It is a lipidated, disulfide-bridged peptide in the amylin and calcitonin receptor agonist class, derived from the biology of amylin, a hormone involved in meal-related satiety and glucose handling.
Research context and categorization
Cagrilintide falls under the metabolic and weight-regulation category of research compounds. It is studied in the context of appetite and satiety signaling and body-weight regulation, and it is commonly discussed in relation to obesity and metabolic research, including the investigational combination with semaglutide known as CagriSema. Some newer study records also investigate amylin-pathway effects on bone metabolism. These uses are investigational. Cagrilintide is not FDA-approved, and the research applications described here are not confirmed or established benefits.
Status
- Regulatory status: Research-only / not FDA-approved. As of 2026 it is an investigational compound under clinical development and is not approved for any indication. It has been studied as part of the CagriSema combination (cagrilintide plus semaglutide), but cagrilintide itself remains research-only outside of trials.
- Sport status: Not specifically listed by name on the WADA Prohibited List, and amylin analogs are not individually named. For context, the World Anti-Doping Agency has been monitoring the broader class of appetite- and weight-regulating peptides, so status can change... consult the current WADA Prohibited List directly before relying on this.
Reconstitution notes (general)
For lyophilized (freeze-dried) peptides, concentration equals the milligrams of powder in the vial divided by the millilitres of bacteriostatic water added. For example, a 10 mg vial reconstituted with 2 mL of bacteriostatic water yields 5 mg/mL, while the same vial with 3 mL yields roughly 3.33 mg/mL. To work out a target concentration without doing the arithmetic by hand, use the calculator at /pages/tools.
Dilution and handling notes (compound-specific)
Cagrilintide ships as a lyophilized (freeze-dried) powder that is reconstituted before use in the lab. Vials commonly contain 5 mg, 10 mg, or 20 mg, often in a 3 mL glass vial, and reported preparations frequently land around 2 to 3 mL of bacteriostatic water per 10 mg vial, giving roughly 3 to 5 mg/mL. That range keeps the peptide dilute enough to dissolve cleanly while keeping the working volume manageable.
The key compound-specific quirk is that amylin analogs, cagrilintide included, have an inherent tendency to aggregate and form amyloid fibrils, and that tendency increases at neutral or alkaline pH and at higher concentrations. In practice the solution should come up clear and colorless. Cloudiness, visible particles, or a thickened, gel-like texture is a sign of aggregation, and material showing those signs should be discarded rather than salvaged. Standard bacteriostatic water (roughly pH 5.5 to 6) is generally treated as acceptable for short-term storage, and some references note that a mildly acidic environment improves longer-term stability against fibril formation.
Handling technique matters more here than with easily soluble peptides. Add the water slowly, aiming the stream at the glass wall rather than onto the powder pellet, to limit foaming and mechanical stress. Do not shake. Swirl or gently roll the vial and let it stand; if it stays hazy, a short rest in the refrigerator before rechecking is the usual approach. Forcing dissolution by vigorous agitation can promote the very aggregation you are trying to avoid.
Handling and storage
Refrigerate reconstituted material at 2 to 8 degrees Celsius and keep it out of light. Wipe the rubber stopper with an alcohol swab before each puncture, and label the vial with the mix date. A reconstituted vial is generally considered usable for about a four-week refrigerated window. Discard anything that turns cloudy or discolored, develops a gel-like texture, or shows floaters or particulates.
Related reading
Tools and supplies
- Reconstitution & blend calculators
- Bacteriostatic Water 30 ml
- Gansulin Metal Reusable Pen
- 3 ml Glass Cartridges (10-pack)
- Complete Starter Kit
For laboratory and research reference only. Educational content, not medical, dosing, injection, or therapeutic guidance, and not intended for human or animal use. Any research uses described are investigational and not confirmed or approved benefits. Confirm anything involving health with a licensed professional. References linked above.