Hexarelin
What it is
Hexarelin (also written examorelin) is a synthetic hexapeptide belonging to the growth hormone secretagogue (GHS) family, and it acts as an agonist at the ghrelin receptor (GHS-R1a). It is one of the growth hormone-releasing peptides (GHRPs), a group that also includes GHRP-2 and GHRP-6.
Research context and categorization
Hexarelin is generally grouped under the growth-hormone secretagogue category. In neutral research terms, it is commonly discussed in relation to its ability to stimulate pulsatile release of growth hormone from the anterior pituitary through a pathway distinct from growth hormone-releasing hormone. Beyond the pituitary, hexarelin is also investigated in the context of cardiac and cardiovascular tissue, because binding sites for growth hormone secretagogues have been described in the heart, and some of the effects studied there appear to be independent of growth hormone itself. It is worth stating plainly that hexarelin is not FDA-approved, so any uses described in the literature are investigational and not confirmed or approved outcomes. Descriptions here reflect what the compound is studied or discussed in the context of, not established benefits.
Status
- Regulatory status: Research-only. Hexarelin is not FDA-approved for any indication and carries no marketing approval in the major jurisdictions that have been surveyed.
- Sport status: Prohibited under the WADA Prohibited List. It falls under class S2 (Peptide Hormones, Growth Factors, Related Substances and Mimetics), specifically among the growth hormone-releasing peptides, and is banned at all times, both in and out of competition.
Reconstitution notes (general)
Hexarelin is supplied as a lyophilized (freeze-dried) powder that is reconstituted before use. Concentration equals the milligrams of peptide in the vial divided by the millilitres of bacteriostatic water added. For example, 5 mg in 2 mL yields 2.5 mg/mL, while 5 mg in 2.5 mL yields 2 mg/mL. Use the reconstitution calculator at /pages/tools to work out the concentration for a given vial and water volume.
Dilution and handling notes (compound-specific)
Hexarelin is most often encountered in 2 mg and 5 mg vials. Typical reconstitution volumes fall in the range of roughly 1 mL to 2.5 mL of bacteriostatic water per vial, and a 1:1 ratio of water to peptide (for example 2 mL of water for a 2 mg vial, giving 1 mg/mL) is a commonly cited starting point because it keeps the arithmetic simple and the solution stable. The choice of water volume is a trade-off. A smaller volume gives a more concentrated solution and a smaller measured draw, while a larger volume spreads the same amount of peptide across more graduations and makes small measurements easier to read.
In practice hexarelin is a well-behaved, readily soluble peptide. It dissolves into a clear, colorless solution and does not typically gel, cloud, or precipitate at the concentrations noted above, so no acidic co-solvent is normally needed. The standard approach is to let the vial come to room temperature first, run the bacteriostatic water slowly down the inner wall of the vial rather than jetting it straight onto the powder, and then swirl gently in a circular motion. Avoid vigorous shaking, which foams the solution, traps peptide in the foam, makes accurate volume measurement difficult, and can stress the material. Give it a couple of minutes and a few gentle swirls to finish dissolving. If a batch does not go fully clear, or shows haze, particles, or discoloration, treat that as a reason to discard rather than to force it into solution. As with any fine lyophilized powder, minimize dust when opening a fresh vial, keep it out of direct light, and avoid repeated freeze-thaw cycles.
Handling and storage
Store reconstituted solution refrigerated at 2 to 8 degrees Celsius and keep it out of light. Wipe the stopper with an alcohol swab before each puncture. Label the vial with the mix date and observe the general working window of about four weeks under refrigeration. Discard any solution that turns cloudy or discolored or that develops floaters.
Related reading
Tools and supplies
- Reconstitution & blend calculators
- Bacteriostatic Water 30 ml
- Gansulin Metal Reusable Pen
- 3 ml Glass Cartridges (10-pack)
- Complete Starter Kit
For laboratory and research reference only. Educational content, not medical, dosing, injection, or therapeutic guidance, and not intended for human or animal use. Any research uses described are investigational and not confirmed or approved benefits. Confirm anything involving health with a licensed professional. References linked above.