CJC-1295
What it is
CJC-1295 is a synthetic peptide analog of growth-hormone-releasing hormone (GHRH), built from the first 29 residues of endogenous GHRH with four amino acid substitutions that make it resistant to enzymatic breakdown in plasma. It exists in two forms: with a Drug Affinity Complex (DAC), which binds albumin to greatly extend its duration, and without DAC (often called modified GRF 1-29), which is shorter-acting.
Research context and categorization
CJC-1295 is generally categorized as a growth-hormone secretagogue, more specifically a GHRH analog or growth-hormone-releasing factor. In research settings it is commonly discussed in relation to stimulating the pituitary to release growth hormone (GH) and, downstream, to raise insulin-like growth factor 1 (IGF-1), while aiming to preserve the natural pulsatile pattern of GH release rather than replacing it directly.
Because of that mechanism, it is studied in the context of GH and IGF-1 secretion dynamics, and it is discussed in relation to areas such as body composition, tissue repair, and metabolic research. These uses are investigational. CJC-1295 is not FDA-approved for any indication, and the outcomes associated with it in popular discussion are not confirmed or approved benefits. Early clinical work in healthy adults examined its ability to prolong GH and IGF-1 elevation, and a development-stage trial was later noted for safety signals that contributed to it not advancing to approval.
Status
- Regulatory status: Research-only / not FDA-approved. CJC-1295 has no approved human therapeutic product in the United States and is sold only as a research-use-only laboratory chemical. It was reviewed by the FDA Pharmacy Compounding Advisory Committee and was not recommended for the 503A bulks list. It is likewise unauthorized as a medicine across the EU and other major jurisdictions.
- Sport status: Prohibited under the WADA Prohibited List. It falls under class S2 (Peptide Hormones, Growth Factors, Related Substances and Mimetics), specifically among growth-hormone-releasing factors and GHRH analogs, and is banned at all times, both in and out of competition. Both the DAC and no-DAC forms are covered.
Reconstitution notes (general)
CJC-1295 is supplied as a lyophilized (freeze-dried) powder that is reconstituted with bacteriostatic water before use in the lab. The working concentration is simply the milligrams in the vial divided by the millilitres of bacteriostatic water added. For example, a 5 mg vial brought up with 2 mL of bacteriostatic water yields 2.5 mg/mL. To convert a target measured amount into a volume once you know the concentration, use the calculator at /pages/tools.
Dilution and handling notes (compound-specific)
CJC-1295 is a true lyophilized peptide, so it does require reconstitution. Vials are commonly supplied at 2 mg or 5 mg, and typical water volumes fall in the roughly 1 mL to 3 mL per vial range. Lower water volumes give a more concentrated solution and a smaller measured volume per unit; higher water volumes make small measurements easier to read but leave a more dilute solution. The choice is a trade-off between concentration and measurement precision, not a dosing instruction.
CJC-1295 generally goes into solution readily and stays clear, so it does not typically gel or precipitate the way some longer or stickier peptides can. The main handling practice is to add the water gently. Aim the stream against the inner glass wall and let it run down onto the powder rather than blasting the pellet directly, then swirl slowly. Do not shake, because agitation can foam the solution and stress the peptide. Let it sit a minute or two to fully dissolve. If any material remains cloudy or fails to clear, that is a sign to discard rather than use.
Handling and storage
Store reconstituted CJC-1295 refrigerated at 2 to 8 C and out of direct light. Wipe the vial stopper with an alcohol swab before each withdrawal, and label the vial with the mix date so the working window is tracked. Reconstituted peptide is generally treated as usable for roughly a four-week refrigerated window, with some references favoring an even shorter window for best stability. Discard the solution if it turns cloudy or discolored or shows any floaters or particulate.
Related reading
Tools and supplies
- Reconstitution & blend calculators
- Bacteriostatic Water 30 ml
- Gansulin Metal Reusable Pen
- 3 ml Glass Cartridges (10-pack)
- Complete Starter Kit
For laboratory and research reference only. Educational content, not medical, dosing, injection, or therapeutic guidance, and not intended for human or animal use. Any research uses described are investigational and not confirmed or approved benefits. Confirm anything involving health with a licensed professional. References linked above.